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Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts
Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectrosco...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402452/ https://www.ncbi.nlm.nih.gov/pubmed/34437491 http://dx.doi.org/10.3390/toxics9080173 |
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| author | Neto, Conrado M. S. Lima, Felipe C. Morais, Renata P. de Andrade, Lucas R. M. de Lima, Renata Chaud, Marco V. Pereira, Matheus M. de Albuquerque Júnior, Ricardo L. C. Cardoso, Juliana C. Zielińska, Aleksandra Souto, Eliana B. Lima, Álvaro S. Severino, Patrícia |
| author_facet | Neto, Conrado M. S. Lima, Felipe C. Morais, Renata P. de Andrade, Lucas R. M. de Lima, Renata Chaud, Marco V. Pereira, Matheus M. de Albuquerque Júnior, Ricardo L. C. Cardoso, Juliana C. Zielińska, Aleksandra Souto, Eliana B. Lima, Álvaro S. Severino, Patrícia |
| author_sort | Neto, Conrado M. S. |
| collection | PubMed |
| description | Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose–effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration. |
| format | Online Article Text |
| id | pubmed-8402452 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84024522021-08-29 Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts Neto, Conrado M. S. Lima, Felipe C. Morais, Renata P. de Andrade, Lucas R. M. de Lima, Renata Chaud, Marco V. Pereira, Matheus M. de Albuquerque Júnior, Ricardo L. C. Cardoso, Juliana C. Zielińska, Aleksandra Souto, Eliana B. Lima, Álvaro S. Severino, Patrícia Toxics Article Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose–effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration. MDPI 2021-07-22 /pmc/articles/PMC8402452/ /pubmed/34437491 http://dx.doi.org/10.3390/toxics9080173 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Neto, Conrado M. S. Lima, Felipe C. Morais, Renata P. de Andrade, Lucas R. M. de Lima, Renata Chaud, Marco V. Pereira, Matheus M. de Albuquerque Júnior, Ricardo L. C. Cardoso, Juliana C. Zielińska, Aleksandra Souto, Eliana B. Lima, Álvaro S. Severino, Patrícia Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts |
| title | Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts |
| title_full | Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts |
| title_fullStr | Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts |
| title_full_unstemmed | Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts |
| title_short | Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts |
| title_sort | rutin-functionalized multi-walled carbon nanotubes: molecular docking, physicochemistry and cytotoxicity in fibroblasts |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402452/ https://www.ncbi.nlm.nih.gov/pubmed/34437491 http://dx.doi.org/10.3390/toxics9080173 |
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