Cargando…

Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5

Galectin-3, which is a novel biomarker of cardiovascular stress and related to inflammation, could predict adverse cardiovascular events. However, its relationship with endothelial function in patients with chronic kidney disease (CKD) remains inconclusive. This study aimed to investigate the associ...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsu, Bang-Gee, Wang, Chih-Hsien, Lai, Yu-Hsien, Tsai, Jen-Pi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402460/
https://www.ncbi.nlm.nih.gov/pubmed/34437403
http://dx.doi.org/10.3390/toxins13080532
_version_ 1783745794972581888
author Hsu, Bang-Gee
Wang, Chih-Hsien
Lai, Yu-Hsien
Tsai, Jen-Pi
author_facet Hsu, Bang-Gee
Wang, Chih-Hsien
Lai, Yu-Hsien
Tsai, Jen-Pi
author_sort Hsu, Bang-Gee
collection PubMed
description Galectin-3, which is a novel biomarker of cardiovascular stress and related to inflammation, could predict adverse cardiovascular events. However, its relationship with endothelial function in patients with chronic kidney disease (CKD) remains inconclusive. This study aimed to investigate the association between serum galectin-3 levels and endothelial function in patients with stages 3–5 CKD. Fasting blood samples were obtained from 130 patients. Serum galectin-3 levels were determined using the enzyme-linked immunosorbent assay. The endothelial function, demonstrated as a vascular reactivity index (VRI), was measured noninvasively through digital thermal monitoring test. Then, we sorted the patients into poor, intermediate, and good vascular reactivity (VRI < 1.0, 1.0 ≤ VRI < 2.0, and VRI ≥ 2.0), accounting for 24 (18.5%), 44 (33.8%), and 62 (47.7%) patients, respectively. As the VRI decreased, the serum galectin-3 and C-reactive protein (CRP) levels significantly increased. The galectin-3 value positively correlated with the CRP value but negatively correlated with estimated glomerular filtration rate. In multivariable stepwise linear regression analysis, serum log-transformed galectin-3 level and log-transformed CRP were significantly negatively associated with VRI values. Therefore, galectin-3 together with CRP is associated with VRI values and is a potential endothelial function modulator and a valuable biomarker of endothelial dysfunction in patients with CKD.
format Online
Article
Text
id pubmed-8402460
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84024602021-08-29 Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5 Hsu, Bang-Gee Wang, Chih-Hsien Lai, Yu-Hsien Tsai, Jen-Pi Toxins (Basel) Article Galectin-3, which is a novel biomarker of cardiovascular stress and related to inflammation, could predict adverse cardiovascular events. However, its relationship with endothelial function in patients with chronic kidney disease (CKD) remains inconclusive. This study aimed to investigate the association between serum galectin-3 levels and endothelial function in patients with stages 3–5 CKD. Fasting blood samples were obtained from 130 patients. Serum galectin-3 levels were determined using the enzyme-linked immunosorbent assay. The endothelial function, demonstrated as a vascular reactivity index (VRI), was measured noninvasively through digital thermal monitoring test. Then, we sorted the patients into poor, intermediate, and good vascular reactivity (VRI < 1.0, 1.0 ≤ VRI < 2.0, and VRI ≥ 2.0), accounting for 24 (18.5%), 44 (33.8%), and 62 (47.7%) patients, respectively. As the VRI decreased, the serum galectin-3 and C-reactive protein (CRP) levels significantly increased. The galectin-3 value positively correlated with the CRP value but negatively correlated with estimated glomerular filtration rate. In multivariable stepwise linear regression analysis, serum log-transformed galectin-3 level and log-transformed CRP were significantly negatively associated with VRI values. Therefore, galectin-3 together with CRP is associated with VRI values and is a potential endothelial function modulator and a valuable biomarker of endothelial dysfunction in patients with CKD. MDPI 2021-07-29 /pmc/articles/PMC8402460/ /pubmed/34437403 http://dx.doi.org/10.3390/toxins13080532 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Bang-Gee
Wang, Chih-Hsien
Lai, Yu-Hsien
Tsai, Jen-Pi
Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5
title Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5
title_full Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5
title_fullStr Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5
title_full_unstemmed Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5
title_short Serum Galectin-3 Level Is Positively Associated with Endothelial Dysfunction in Patients with Chronic Kidney Disease Stage 3 to 5
title_sort serum galectin-3 level is positively associated with endothelial dysfunction in patients with chronic kidney disease stage 3 to 5
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402460/
https://www.ncbi.nlm.nih.gov/pubmed/34437403
http://dx.doi.org/10.3390/toxins13080532
work_keys_str_mv AT hsubanggee serumgalectin3levelispositivelyassociatedwithendothelialdysfunctioninpatientswithchronickidneydiseasestage3to5
AT wangchihhsien serumgalectin3levelispositivelyassociatedwithendothelialdysfunctioninpatientswithchronickidneydiseasestage3to5
AT laiyuhsien serumgalectin3levelispositivelyassociatedwithendothelialdysfunctioninpatientswithchronickidneydiseasestage3to5
AT tsaijenpi serumgalectin3levelispositivelyassociatedwithendothelialdysfunctioninpatientswithchronickidneydiseasestage3to5