Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Intranasal vaccination is an attractive strategy to prevent COVID-19 as the nasal mucosa repr...

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Detalles Bibliográficos
Autores principales: King, R. Glenn, Silva-Sanchez, Aaron, Peel, Jessica N., Botta, Davide, Dickson, Alexandria M., Pinto, Amelia K., Meza-Perez, Selene, Allie, S. Rameeza, Schultz, Michael D., Liu, Mingyong, Bradley, John E., Qiu, Shihong, Yang, Guang, Zhou, Fen, Zumaquero, Esther, Simpler, Thomas S., Mousseau, Betty, Killian, John T., Dean, Brittany, Shang, Qiao, Tipper, Jennifer L., Risley, Christopher A., Harrod, Kevin S., Feng, Tsungwei, Lee, Young, Shiberu, Bethlehem, Krishnan, Vyjayanthi, Peguillet, Isabelle, Zhang, Jianfeng, Green, Todd J., Randall, Troy D., Suschak, John J., Georges, Bertrand, Brien, James D., Lund, Frances E., Roberts, M. Scot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402488/
https://www.ncbi.nlm.nih.gov/pubmed/34452006
http://dx.doi.org/10.3390/vaccines9080881

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