Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions

Escherichia coli (E. coli) of the B2 phylotype reside in human and animal intestines. The bacteria possess pathogenicity factors such as α-hemolysin (HlyA) that can induce intestinal epithelial leaks. We addressed the questions which host cell processes were dysregulated by E. coli HlyA that can pot...

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Detalles Bibliográficos
Autores principales: Schulz, Emanuel, Schumann, Michael, Schneemann, Martina, Dony, Violaine, Fromm, Anja, Nagel, Oliver, Schulzke, Jörg-Dieter, Bücker, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402498/
https://www.ncbi.nlm.nih.gov/pubmed/34437391
http://dx.doi.org/10.3390/toxins13080520

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