Cargando…

Elucidating the Venom Diversity in Sri Lankan Spectacled Cobra (Naja naja) through De Novo Venom Gland Transcriptomics, Venom Proteomics and Toxicity Neutralization

Inadequate effectiveness of Indian antivenoms in treating envenomation caused by the Spectacled Cobra/Indian Cobra (Naja naja) in Sri Lanka has been attributed to geographical variations in the venom composition. This study investigated the de novo venom-gland transcriptomics and venom proteomics of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wong, Kin Ying, Tan, Kae Yi, Tan, Nget Hong, Gnanathasan, Christeine Ariaranee, Tan, Choo Hock
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402536/ https://www.ncbi.nlm.nih.gov/pubmed/34437429 http://dx.doi.org/10.3390/toxins13080558

Ejemplares similares

Comparative venom gland transcriptomics of Naja kaouthia (monocled cobra) from Malaysia and Thailand: elucidating geographical venom variation and insights into sequence novelty
por: Tan, Kae Yi, et al.
Publicado: (2017)

Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell’s viper (Daboia russelii) venoms
por: Faisal, Tasnim, et al.
Publicado: (2021)

Snake Venomics and Antivenomics of Cape Cobra (Naja nivea) from South Africa: Insights into Venom Toxicity and Cross-Neutralization Activity
por: Tan, Choo Hock, et al.
Publicado: (2022)

A Neurotoxic Snake Venom without Phospholipase A(2): Proteomics and Cross-Neutralization of the Venom from Senegalese Cobra, Naja senegalensis (Subgenus: Uraeus)
por: Wong, Kin Ying, et al.
Publicado: (2021)

The Venom of Spectacled Cobra (Elapidae: Naja naja): In Vitro Study from Distinct Geographical Origins in Sri Lanka
por: Dissanayake, Duminda S. B., et al.
Publicado: (2018)

Distinctive Distribution of Secretory Phospholipases A(2) in the Venoms of Afro-Asian Cobras (Subgenus: Naja, Afronaja, Boulengerina and Uraeus)
por: Tan, Choo Hock, et al.
Publicado: (2019)

Cytotoxicity of Venoms and Cytotoxins from Asiatic Cobras (Naja kaouthia, Naja sumatrana, Naja atra) and Neutralization by Antivenoms from Thailand, Vietnam, and Taiwan
por: Chong, Ho Phin, et al.
Publicado: (2022)

Exploring the Diversity and Novelty of Toxin Genes in Naja sumatrana, the Equatorial Spitting Cobra from Malaysia through De Novo Venom-Gland Transcriptomics
por: Chong, Ho Phin, et al.
Publicado: (2019)

The Venom of Indian Cobra (Naja Naja) in Certain Painful Conditions
por: Chopra, R. N., et al.
Publicado: (1940)

Pharmacokinetics of Naja sumatrana (Equatorial Spitting Cobra) Venom and Its Major Toxins in Experimentally Envenomed Rabbits
por: Yap, Michelle Khai Khun, et al.
Publicado: (2014)

Cytotoxicity of Snake Venoms and Cytotoxins From Two Southeast Asian Cobras (Naja sumatrana, Naja kaouthia): Exploration of Anticancer Potential, Selectivity, and Cell Death Mechanism
por: Chong, Ho Phin, et al.
Publicado: (2020)

Equatorial Spitting Cobra (Naja sumatrana) from Malaysia (Negeri Sembilan and Penang), Southern Thailand, and Sumatra: Comparative Venom Proteomics, Immunoreactivity and Cross-Neutralization by Antivenom
por: Tan, Choo Hock, et al.
Publicado: (2022)

Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah)
por: Tan, Choo Hock, et al.
Publicado: (2015)

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy
por: Senji Laxme, R. R., et al.
Publicado: (2021)

The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy
por: Wang, Shu-Zhi, et al.
Publicado: (2013)

Protein Identification of Venoms of the African Spitting Cobras, Naja mossambica and Naja nigricincta nigricincta
por: Katali, Ottilie, et al.
Publicado: (2020)

Isolation and Characterization of Two Postsynaptic Neurotoxins From Indian Cobra (Naja Naja) Venom
por: Huynh, Tam M., et al.
Publicado: (2022)

Snake Venom Proteomics of Samar Cobra (Naja samarensis) from the Southern Philippines: Short Alpha-Neurotoxins as the Dominant Lethal Component Weakly Cross-Neutralized by the Philippine Cobra Antivenom
por: Palasuberniam, Praneetha, et al.
Publicado: (2021)

Neutralization of the Principal Toxins from the Venoms of Thai Naja kaouthia and Malaysian Hydrophis schistosus: Insights into Toxin-Specific Neutralization by Two Different Antivenoms
por: Tan, Kae Yi, et al.
Publicado: (2016)

Differential Effects of Naja naja atra Venom on Immune Activity
por: Kou, Jian-Qun, et al.
Publicado: (2014)

Effect of Indian Polyvalent Antivenom in the Prevention and Reversal of Local Myotoxicity Induced by Common Cobra (Naja naja) Venom from Sri Lanka In Vitro
por: Madhushani, Umesha, et al.
Publicado: (2021)

Antibacterial Activity of Venom from the Puff Adder (Bitis arietans), Egyptian Cobra (Naja haje), and Red Spitting Cobra (Naja pallida)
por: Okumu, Mitchel Otieno, et al.
Publicado: (2023)

Characterization of Daboia russelii and Naja naja venom neutralizing ability of an undocumented indigenous medication in Sri Lanka
por: Silva, Madhushika M., et al.
Publicado: (2017)

First Look at the Venom of Naja ashei
por: Hus, Konrad Kamil, et al.
Publicado: (2018)

Proteomic characterization of Naja mandalayensis venom
por: Beraldo, Emídio, et al.
Publicado: (2021)

Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom
por: Wang, Shu-Zhi, et al.
Publicado: (2018)

Antibacterial Activity of Isolated Immunodominant Proteins of Naja Naja (Oxiana) Venom
por: talebi mehrdar, Mahboobeh, et al.
Publicado: (2017)

Antibacterial activity of an acidic phospholipase A(2) (NN-XIb-PLA(2)) from the venom of Naja naja (Indian cobra)
por: Sudarshan, S., et al.
Publicado: (2016)

An Examination of the Neutralization of In Vitro Toxicity of Chinese Cobra (Naja atra) Venom by Different Antivenoms
por: Liang, Qing, et al.
Publicado: (2020)

Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats
por: Wang, Shu-Zhi, et al.
Publicado: (2015)

In vitro and in vivo inhibitory effects of Tabernaemontana alternifolia against Naja naja venom
por: Vineetha, M.S., et al.
Publicado: (2020)

Impact of Naja nigricollis Venom on the Production of Methaemoglobin
por: Williams, Harry F., et al.
Publicado: (2018)

Proteome of monocled cobra (Naja kaouthia) venom and potent anti breast cancer peptide from trypsin hydrolyzate of the venom protein
por: Erlista, Garnis Putri, et al.
Publicado: (2023)

Naja naja oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic Three-Fingered Cytotoxins
por: Gasanov, Sardar E., et al.
Publicado: (2015)

Anticancer Activity a of Caspian Cobra (Naja naja oxiana) snake Venom in Human Cancer Cell Lines Via Induction of Apoptosis
por: Ebrahim, Karim, et al.
Publicado: (2016)

Effect of Mucuna pruriens Seed Extract Pretreatment on the Responses of Spontaneously Beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra) Venom
por: Fung, Shin Yee, et al.
Publicado: (2012)

Anti-snake venom and methanolic extract of Andrographis paniculata: a multipronged strategy to neutralize Naja naja venom acetylcholinesterase and hyaluronidase
por: Nayak, Akshatha Ganesh, et al.
Publicado: (2020)

Antitoxin activity of aqueous extract of Cyclea peltata root against Naja naja venom
por: Sivaraman, Thulasi, et al.
Publicado: (2017)

Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress
por: Cui, Kui, et al.
Publicado: (2014)

Characterization of Chicken-Derived Single Chain Antibody Fragments against Venom of Naja Naja Atra
por: Lee, Chi-Hsin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_j2pq0642vd58rg8hi005pnaoil