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Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study
Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor pr...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402601/ https://www.ncbi.nlm.nih.gov/pubmed/34437440 http://dx.doi.org/10.3390/toxins13080569 |
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author | Piciocchi, Alfonso Germinario, Elena Angela Pia Garcia Etxebarria, Koldo Rossi, Silvia Sanchez-Mete, Lupe Porowska, Barbara Stigliano, Vittoria Trentino, Paolo Oddi, Andrea Accarpio, Fabio Grazi, Gian Luca Bruno, Giovanni Bonucci, Massimo Giambenedetti, Massimo Spigaglia, Patrizia Barbanti, Fabrizio Owczarek, Slawomir Luzzi, Ida Delibato, Elisabetta Maroccia, Zaira Nisticò, Lorenza Fiorentini, Carla D’Amato, Mauro De Angelis, Roberta Fabbri, Alessia |
author_facet | Piciocchi, Alfonso Germinario, Elena Angela Pia Garcia Etxebarria, Koldo Rossi, Silvia Sanchez-Mete, Lupe Porowska, Barbara Stigliano, Vittoria Trentino, Paolo Oddi, Andrea Accarpio, Fabio Grazi, Gian Luca Bruno, Giovanni Bonucci, Massimo Giambenedetti, Massimo Spigaglia, Patrizia Barbanti, Fabrizio Owczarek, Slawomir Luzzi, Ida Delibato, Elisabetta Maroccia, Zaira Nisticò, Lorenza Fiorentini, Carla D’Amato, Mauro De Angelis, Roberta Fabbri, Alessia |
author_sort | Piciocchi, Alfonso |
collection | PubMed |
description | Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this study, we recruited more than 300 biopsy specimens from people undergoing colonoscopy, and we analyzed to determine whether a correlation exists between the presence of bacterial genes coding for toxins possibly involved in CRC onset and progression and the different stages of CRC. We also analyzed to determine whether CRC-predisposing genetic factors could contribute to bacterial toxins response. Our results showed that CIF toxin is associated with polyps or adenomas, whereas pks+ seems to be a predisposing factor for CRC. Toxins from Escherichia coli as a whole have a higher incidence rate in adenocarcinoma patients compared to controls, whereas Bacteroides fragilis toxin does not seem to be associated with pre-cancerous nor with cancerous lesions. These results have been obtained irrespectively of the presence of CRC-risk loci. |
format | Online Article Text |
id | pubmed-8402601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84026012021-08-29 Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study Piciocchi, Alfonso Germinario, Elena Angela Pia Garcia Etxebarria, Koldo Rossi, Silvia Sanchez-Mete, Lupe Porowska, Barbara Stigliano, Vittoria Trentino, Paolo Oddi, Andrea Accarpio, Fabio Grazi, Gian Luca Bruno, Giovanni Bonucci, Massimo Giambenedetti, Massimo Spigaglia, Patrizia Barbanti, Fabrizio Owczarek, Slawomir Luzzi, Ida Delibato, Elisabetta Maroccia, Zaira Nisticò, Lorenza Fiorentini, Carla D’Amato, Mauro De Angelis, Roberta Fabbri, Alessia Toxins (Basel) Article Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this study, we recruited more than 300 biopsy specimens from people undergoing colonoscopy, and we analyzed to determine whether a correlation exists between the presence of bacterial genes coding for toxins possibly involved in CRC onset and progression and the different stages of CRC. We also analyzed to determine whether CRC-predisposing genetic factors could contribute to bacterial toxins response. Our results showed that CIF toxin is associated with polyps or adenomas, whereas pks+ seems to be a predisposing factor for CRC. Toxins from Escherichia coli as a whole have a higher incidence rate in adenocarcinoma patients compared to controls, whereas Bacteroides fragilis toxin does not seem to be associated with pre-cancerous nor with cancerous lesions. These results have been obtained irrespectively of the presence of CRC-risk loci. MDPI 2021-08-16 /pmc/articles/PMC8402601/ /pubmed/34437440 http://dx.doi.org/10.3390/toxins13080569 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Piciocchi, Alfonso Germinario, Elena Angela Pia Garcia Etxebarria, Koldo Rossi, Silvia Sanchez-Mete, Lupe Porowska, Barbara Stigliano, Vittoria Trentino, Paolo Oddi, Andrea Accarpio, Fabio Grazi, Gian Luca Bruno, Giovanni Bonucci, Massimo Giambenedetti, Massimo Spigaglia, Patrizia Barbanti, Fabrizio Owczarek, Slawomir Luzzi, Ida Delibato, Elisabetta Maroccia, Zaira Nisticò, Lorenza Fiorentini, Carla D’Amato, Mauro De Angelis, Roberta Fabbri, Alessia Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study |
title | Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study |
title_full | Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study |
title_fullStr | Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study |
title_full_unstemmed | Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study |
title_short | Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study |
title_sort | association of polygenic risk score and bacterial toxins at screening colonoscopy with colorectal cancer progression: a multicenter case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402601/ https://www.ncbi.nlm.nih.gov/pubmed/34437440 http://dx.doi.org/10.3390/toxins13080569 |
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