Cargando…
Guiding the Immune Response to a Conserved Epitope in MSP2, an Intrinsically Disordered Malaria Vaccine Candidate
The malaria vaccine candidate merozoite surface protein 2 (MSP2) has shown promise in clinical trials and is in part responsible for a reduction in parasite densities. However, strain-specific reductions in parasitaemia suggested that polymorphic regions of MSP2 are immuno-dominant. One strategy to...
Autores principales: | Seow, Jeffrey, Das, Sreedam C., Morales, Rodrigo A. V., Ataide, Ricardo, Krishnarjuna, Bankala, Silk, Mitchell, Chalmers, David K., Richards, Jack, Anders, Robin F., MacRaild, Christopher A., Norton, Raymond S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402609/ https://www.ncbi.nlm.nih.gov/pubmed/34451980 http://dx.doi.org/10.3390/vaccines9080855 |
Ejemplares similares
-
Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate
por: Morales, Rodrigo A. V., et al.
Publicado: (2015) -
Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope
por: Krishnarjuna, Bankala, et al.
Publicado: (2018) -
Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2
por: Krishnarjuna, Bankala, et al.
Publicado: (2016) -
Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2
por: MacRaild, Christopher A., et al.
Publicado: (2015) -
Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions
por: Guy, Andrew J., et al.
Publicado: (2015)