Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening

The hepatic bile acid transporter Na(+)/taurocholate co-transporting polypeptide (NTCP) was identified in 2012 as the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV). Since then, this carrier has emerged as promising drug target for HBV/HDV virus entry inhibitors, but the...

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Detalles Bibliográficos
Autores principales: Kirstgen, Michael, Müller, Simon Franz, Lowjaga, Kira Alessandra Alicia Theresa, Goldmann, Nora, Lehmann, Felix, Alakurtti, Sami, Yli-Kauhaluoma, Jari, Baringhaus, Karl-Heinz, Krieg, Reimar, Glebe, Dieter, Geyer, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402622/
https://www.ncbi.nlm.nih.gov/pubmed/34452354
http://dx.doi.org/10.3390/v13081489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402622/
https://www.ncbi.nlm.nih.gov/pubmed/34452354
http://dx.doi.org/10.3390/v13081489

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