The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

Cytoplasmic aggregation of the primarily nuclear TAR DNA-binding protein 43 (TDP-43) affects neurons in most amyotrophic lateral sclerosis (ALS) and approximately half of frontotemporal lobar degeneration (FTLD) cases. The cellular prion protein, PrP(C), has been recognized as a common receptor and...

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Detalles Bibliográficos
Autores principales: Scialò, Carlo, Celauro, Luigi, Zattoni, Marco, Tran, Thanh Hoa, Bistaffa, Edoardo, Moda, Fabio, Kammerer, Robert, Buratti, Emanuele, Legname, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402629/
https://www.ncbi.nlm.nih.gov/pubmed/34452489
http://dx.doi.org/10.3390/v13081625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402629/
https://www.ncbi.nlm.nih.gov/pubmed/34452489
http://dx.doi.org/10.3390/v13081625

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