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Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)

The sandfly fever Toscana virus (TOSV, genus Phlebovirus, family Phenuiviridae) is endemic in Mediterranean countries. In Spain, phylogenetic studies of TOSV strains demonstrated that a genotype, different from the Italian, was circulating. This update reports 107 cases of TOSV neurological infectio...

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Autores principales: Sanbonmatsu-Gámez, Sara, Pedrosa-Corral, Irene, Navarro-Marí, José María, Pérez-Ruiz, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402649/
https://www.ncbi.nlm.nih.gov/pubmed/34452304
http://dx.doi.org/10.3390/v13081438
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author Sanbonmatsu-Gámez, Sara
Pedrosa-Corral, Irene
Navarro-Marí, José María
Pérez-Ruiz, Mercedes
author_facet Sanbonmatsu-Gámez, Sara
Pedrosa-Corral, Irene
Navarro-Marí, José María
Pérez-Ruiz, Mercedes
author_sort Sanbonmatsu-Gámez, Sara
collection PubMed
description The sandfly fever Toscana virus (TOSV, genus Phlebovirus, family Phenuiviridae) is endemic in Mediterranean countries. In Spain, phylogenetic studies of TOSV strains demonstrated that a genotype, different from the Italian, was circulating. This update reports 107 cases of TOSV neurological infection detected in Andalusia from 1988 to 2020, by viral culture, serology and/or RT-PCR. Most cases were located in Granada province, a hyperendemic region. TOSV neurological infection may be underdiagnosed since few laboratories include this virus in their portfolio. This work presents a reliable automated method, validated for the detection of the main viruses involved in acute meningitis and encephalitis, including the arboviruses TOSV and West Nile virus. This assay solves the need for multiple molecular platforms for different viruses and thus, improves the time to results for these syndromes, which require a rapid and efficient diagnostic approach.
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spelling pubmed-84026492021-08-29 Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain) Sanbonmatsu-Gámez, Sara Pedrosa-Corral, Irene Navarro-Marí, José María Pérez-Ruiz, Mercedes Viruses Article The sandfly fever Toscana virus (TOSV, genus Phlebovirus, family Phenuiviridae) is endemic in Mediterranean countries. In Spain, phylogenetic studies of TOSV strains demonstrated that a genotype, different from the Italian, was circulating. This update reports 107 cases of TOSV neurological infection detected in Andalusia from 1988 to 2020, by viral culture, serology and/or RT-PCR. Most cases were located in Granada province, a hyperendemic region. TOSV neurological infection may be underdiagnosed since few laboratories include this virus in their portfolio. This work presents a reliable automated method, validated for the detection of the main viruses involved in acute meningitis and encephalitis, including the arboviruses TOSV and West Nile virus. This assay solves the need for multiple molecular platforms for different viruses and thus, improves the time to results for these syndromes, which require a rapid and efficient diagnostic approach. MDPI 2021-07-23 /pmc/articles/PMC8402649/ /pubmed/34452304 http://dx.doi.org/10.3390/v13081438 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sanbonmatsu-Gámez, Sara
Pedrosa-Corral, Irene
Navarro-Marí, José María
Pérez-Ruiz, Mercedes
Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)
title Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)
title_full Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)
title_fullStr Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)
title_full_unstemmed Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)
title_short Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)
title_sort update in diagnostics of toscana virus infection in a hyperendemic region (southern spain)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402649/
https://www.ncbi.nlm.nih.gov/pubmed/34452304
http://dx.doi.org/10.3390/v13081438
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