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TBE Vaccination Breakthrough Cases—Does Age Matter?

Tick-borne encephalitis (TBE) vaccines are highly effective in preventing TBE and vaccine failures (VF) are rare events. In this study, we compared the age distribution of TBE cases and TBE VF in three endemic countries: Sweden, Southern Germany, and Latvia. While the age distribution of TBE cases w...

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Autores principales: Schmitt, Heinz-J., Dobler, Gerhard, Zavadska, Dace, Freimane, Zane, Fousteris, Dimitrios, Erber, Wilhelm, Jodar, Luis, Palmborg, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402669/
https://www.ncbi.nlm.nih.gov/pubmed/34452056
http://dx.doi.org/10.3390/vaccines9080932
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author Schmitt, Heinz-J.
Dobler, Gerhard
Zavadska, Dace
Freimane, Zane
Fousteris, Dimitrios
Erber, Wilhelm
Jodar, Luis
Palmborg, Andreas
author_facet Schmitt, Heinz-J.
Dobler, Gerhard
Zavadska, Dace
Freimane, Zane
Fousteris, Dimitrios
Erber, Wilhelm
Jodar, Luis
Palmborg, Andreas
author_sort Schmitt, Heinz-J.
collection PubMed
description Tick-borne encephalitis (TBE) vaccines are highly effective in preventing TBE and vaccine failures (VF) are rare events. In this study, we compared the age distribution of TBE cases and TBE VF in three endemic countries: Sweden, Southern Germany, and Latvia. While the age distribution of TBE cases was similar for those <50 years versus those ≥50 years in all three countries, in Sweden, a higher proportion of VF cases was ≥50 years, whereas most VF cases in Latvia were <50 years of age and more evenly distributed between those <50 years versus those ≥50 in Southern Germany. Here, theoretical explanations were provided, including differences in diagnostic practices, vaccine uptake between age groups, behavioral patterns and underlying medical conditions, as to why VF were generally older in Sweden than the other countries. There is no scientific rationale to give an extra priming dose of TBE vaccine to subjects ≥50 years of age.
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spelling pubmed-84026692021-08-29 TBE Vaccination Breakthrough Cases—Does Age Matter? Schmitt, Heinz-J. Dobler, Gerhard Zavadska, Dace Freimane, Zane Fousteris, Dimitrios Erber, Wilhelm Jodar, Luis Palmborg, Andreas Vaccines (Basel) Communication Tick-borne encephalitis (TBE) vaccines are highly effective in preventing TBE and vaccine failures (VF) are rare events. In this study, we compared the age distribution of TBE cases and TBE VF in three endemic countries: Sweden, Southern Germany, and Latvia. While the age distribution of TBE cases was similar for those <50 years versus those ≥50 years in all three countries, in Sweden, a higher proportion of VF cases was ≥50 years, whereas most VF cases in Latvia were <50 years of age and more evenly distributed between those <50 years versus those ≥50 in Southern Germany. Here, theoretical explanations were provided, including differences in diagnostic practices, vaccine uptake between age groups, behavioral patterns and underlying medical conditions, as to why VF were generally older in Sweden than the other countries. There is no scientific rationale to give an extra priming dose of TBE vaccine to subjects ≥50 years of age. MDPI 2021-08-21 /pmc/articles/PMC8402669/ /pubmed/34452056 http://dx.doi.org/10.3390/vaccines9080932 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Schmitt, Heinz-J.
Dobler, Gerhard
Zavadska, Dace
Freimane, Zane
Fousteris, Dimitrios
Erber, Wilhelm
Jodar, Luis
Palmborg, Andreas
TBE Vaccination Breakthrough Cases—Does Age Matter?
title TBE Vaccination Breakthrough Cases—Does Age Matter?
title_full TBE Vaccination Breakthrough Cases—Does Age Matter?
title_fullStr TBE Vaccination Breakthrough Cases—Does Age Matter?
title_full_unstemmed TBE Vaccination Breakthrough Cases—Does Age Matter?
title_short TBE Vaccination Breakthrough Cases—Does Age Matter?
title_sort tbe vaccination breakthrough cases—does age matter?
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402669/
https://www.ncbi.nlm.nih.gov/pubmed/34452056
http://dx.doi.org/10.3390/vaccines9080932
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