Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated...

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Detalles Bibliográficos
Autores principales: Johnson, Reed F., Keith, Lauren A., Cooper, Timothy K., Yellayi, Srikanth, Josleyn, Nicole M., Janosko, Krisztina B., Pettitt, James D., Thomasson, David, Hagen, Katie R., Gross, Robin, Bernbaum, John G., Douglas, Debbie, Solomon, Jeffrey, Martinez, Mark, Cooper, Kurt, St. Claire, Marisa, Ragland, Danny R., Jahrling, Peter B., Kuhn, Jens H., Arai, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402688/
https://www.ncbi.nlm.nih.gov/pubmed/34452435
http://dx.doi.org/10.3390/v13081571
Descripción
Sumario:Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox.

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