Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated...

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Autores principales: Johnson, Reed F., Keith, Lauren A., Cooper, Timothy K., Yellayi, Srikanth, Josleyn, Nicole M., Janosko, Krisztina B., Pettitt, James D., Thomasson, David, Hagen, Katie R., Gross, Robin, Bernbaum, John G., Douglas, Debbie, Solomon, Jeffrey, Martinez, Mark, Cooper, Kurt, St. Claire, Marisa, Ragland, Danny R., Jahrling, Peter B., Kuhn, Jens H., Arai, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402688/
https://www.ncbi.nlm.nih.gov/pubmed/34452435
http://dx.doi.org/10.3390/v13081571
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author Johnson, Reed F.
Keith, Lauren A.
Cooper, Timothy K.
Yellayi, Srikanth
Josleyn, Nicole M.
Janosko, Krisztina B.
Pettitt, James D.
Thomasson, David
Hagen, Katie R.
Gross, Robin
Bernbaum, John G.
Douglas, Debbie
Solomon, Jeffrey
Martinez, Mark
Cooper, Kurt
St. Claire, Marisa
Ragland, Danny R.
Jahrling, Peter B.
Kuhn, Jens H.
Arai, Andrew E.
author_facet Johnson, Reed F.
Keith, Lauren A.
Cooper, Timothy K.
Yellayi, Srikanth
Josleyn, Nicole M.
Janosko, Krisztina B.
Pettitt, James D.
Thomasson, David
Hagen, Katie R.
Gross, Robin
Bernbaum, John G.
Douglas, Debbie
Solomon, Jeffrey
Martinez, Mark
Cooper, Kurt
St. Claire, Marisa
Ragland, Danny R.
Jahrling, Peter B.
Kuhn, Jens H.
Arai, Andrew E.
author_sort Johnson, Reed F.
collection PubMed
description Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox.
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spelling pubmed-84026882021-08-29 Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox Johnson, Reed F. Keith, Lauren A. Cooper, Timothy K. Yellayi, Srikanth Josleyn, Nicole M. Janosko, Krisztina B. Pettitt, James D. Thomasson, David Hagen, Katie R. Gross, Robin Bernbaum, John G. Douglas, Debbie Solomon, Jeffrey Martinez, Mark Cooper, Kurt St. Claire, Marisa Ragland, Danny R. Jahrling, Peter B. Kuhn, Jens H. Arai, Andrew E. Viruses Article Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox. MDPI 2021-08-09 /pmc/articles/PMC8402688/ /pubmed/34452435 http://dx.doi.org/10.3390/v13081571 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Johnson, Reed F.
Keith, Lauren A.
Cooper, Timothy K.
Yellayi, Srikanth
Josleyn, Nicole M.
Janosko, Krisztina B.
Pettitt, James D.
Thomasson, David
Hagen, Katie R.
Gross, Robin
Bernbaum, John G.
Douglas, Debbie
Solomon, Jeffrey
Martinez, Mark
Cooper, Kurt
St. Claire, Marisa
Ragland, Danny R.
Jahrling, Peter B.
Kuhn, Jens H.
Arai, Andrew E.
Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
title Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
title_full Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
title_fullStr Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
title_full_unstemmed Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
title_short Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox
title_sort acute late-stage myocarditis in the crab-eating macaque model of hemorrhagic smallpox
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402688/
https://www.ncbi.nlm.nih.gov/pubmed/34452435
http://dx.doi.org/10.3390/v13081571
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