APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma

APOBEC is a mutagenic source in human papillomavirus (HPV)-mediated malignancies, including HPV+ oropharyngeal squamous cell carcinoma (HPV + OPSCC), and in HPV genomes. It is unknown why APOBEC mutations predominate in HPV + OPSCC, or if the APOBEC-induced mutations observed in both human cancers a...

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Detalles Bibliográficos
Autores principales: Faden, Daniel L., Kuhs, Krystle A. Lang, Lin, Maoxuan, Langenbucher, Adam, Pinheiro, Maisa, Yeager, Meredith, Cullen, Michael, Boland, Joseph F., Steinberg, Mia, Bass, Sara, Lewis, James S., Lawrence, Michael S., Ferris, Robert L., Mirabello, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402723/
https://www.ncbi.nlm.nih.gov/pubmed/34452530
http://dx.doi.org/10.3390/v13081666

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