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The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany

In May 2021, the Alpha variant (B.1.1.7) of SARS-CoV-2 was found in 91% of the SARS-CoV-2 cases in Germany. Not much is known about the symptoms, courses of disease, and infectiousness in pediatric patients with the Alpha variant. Objective: The aim of this retrospective analysis was to gain informa...

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Autores principales: Meyer, Meike, Holfter, Anna, Ruebsteck, Esra, Gruell, Henning, Dewald, Felix, Koerner, Robert Walter, Klein, Florian, Lehmann, Clara, Huenseler, Christoph, Weber, Lutz Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402740/
https://www.ncbi.nlm.nih.gov/pubmed/34452464
http://dx.doi.org/10.3390/v13081600
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author Meyer, Meike
Holfter, Anna
Ruebsteck, Esra
Gruell, Henning
Dewald, Felix
Koerner, Robert Walter
Klein, Florian
Lehmann, Clara
Huenseler, Christoph
Weber, Lutz Thorsten
author_facet Meyer, Meike
Holfter, Anna
Ruebsteck, Esra
Gruell, Henning
Dewald, Felix
Koerner, Robert Walter
Klein, Florian
Lehmann, Clara
Huenseler, Christoph
Weber, Lutz Thorsten
author_sort Meyer, Meike
collection PubMed
description In May 2021, the Alpha variant (B.1.1.7) of SARS-CoV-2 was found in 91% of the SARS-CoV-2 cases in Germany. Not much is known about the symptoms, courses of disease, and infectiousness in pediatric patients with the Alpha variant. Objective: The aim of this retrospective analysis was to gain information on the infection with the Alpha variant in children and adolescents. Methods: Between 12 January 2021 and 3 June 2021, all nucleic acid amplification tests (NAATs) of children who received a swab for SARS-CoV-2 were included. Data were collected on standardized questionnaires. The analysis of data was anonymized and retrospective. Results: We investigated 3544 NAATs; 95 children were tested positive (2.7%) for SARS-CoV-2. For the sub-analysis, 65 children were analyzed. In 59 children, the Alpha variant was found (90.8%), and 54.2% (n = 32/59) were symptomatic. The most common symptoms were fever, cough, and rhinitis. The median Ct value was 24.0 (min 17.0; max 32.7). Conclusions: We can underline early findings that children are still less effected by SARS-CoV-2 infection with the spread of the Alpha variant. We found no evidence that children infected with the Alpha variant showed more severe symptoms or suffered from a more severe clinical course than those infected with the wild type.
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spelling pubmed-84027402021-08-29 The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany Meyer, Meike Holfter, Anna Ruebsteck, Esra Gruell, Henning Dewald, Felix Koerner, Robert Walter Klein, Florian Lehmann, Clara Huenseler, Christoph Weber, Lutz Thorsten Viruses Article In May 2021, the Alpha variant (B.1.1.7) of SARS-CoV-2 was found in 91% of the SARS-CoV-2 cases in Germany. Not much is known about the symptoms, courses of disease, and infectiousness in pediatric patients with the Alpha variant. Objective: The aim of this retrospective analysis was to gain information on the infection with the Alpha variant in children and adolescents. Methods: Between 12 January 2021 and 3 June 2021, all nucleic acid amplification tests (NAATs) of children who received a swab for SARS-CoV-2 were included. Data were collected on standardized questionnaires. The analysis of data was anonymized and retrospective. Results: We investigated 3544 NAATs; 95 children were tested positive (2.7%) for SARS-CoV-2. For the sub-analysis, 65 children were analyzed. In 59 children, the Alpha variant was found (90.8%), and 54.2% (n = 32/59) were symptomatic. The most common symptoms were fever, cough, and rhinitis. The median Ct value was 24.0 (min 17.0; max 32.7). Conclusions: We can underline early findings that children are still less effected by SARS-CoV-2 infection with the spread of the Alpha variant. We found no evidence that children infected with the Alpha variant showed more severe symptoms or suffered from a more severe clinical course than those infected with the wild type. MDPI 2021-08-12 /pmc/articles/PMC8402740/ /pubmed/34452464 http://dx.doi.org/10.3390/v13081600 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meyer, Meike
Holfter, Anna
Ruebsteck, Esra
Gruell, Henning
Dewald, Felix
Koerner, Robert Walter
Klein, Florian
Lehmann, Clara
Huenseler, Christoph
Weber, Lutz Thorsten
The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany
title The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany
title_full The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany
title_fullStr The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany
title_full_unstemmed The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany
title_short The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany
title_sort alpha variant (b.1.1.7) of sars-cov-2 in children: first experience from 3544 nucleic acid amplification tests in a cohort of children in germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402740/
https://www.ncbi.nlm.nih.gov/pubmed/34452464
http://dx.doi.org/10.3390/v13081600
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