Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We...

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Detalles Bibliográficos
Autores principales: Castelli, Matteo, Baj, Andreina, Criscuolo, Elena, Ferrarese, Roberto, Diotti, Roberta A., Sampaolo, Michela, Novazzi, Federica, Dalla Gasperina, Daniela, Focosi, Daniele, Ferrari, Davide, Locatelli, Massimo, Clementi, Massimo, Clementi, Nicola, Maggi, Fabrizio, Mancini, Nicasio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402759/
https://www.ncbi.nlm.nih.gov/pubmed/34452380
http://dx.doi.org/10.3390/v13081514
Descripción
Sumario:SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.

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