Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We...

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Autores principales: Castelli, Matteo, Baj, Andreina, Criscuolo, Elena, Ferrarese, Roberto, Diotti, Roberta A., Sampaolo, Michela, Novazzi, Federica, Dalla Gasperina, Daniela, Focosi, Daniele, Ferrari, Davide, Locatelli, Massimo, Clementi, Massimo, Clementi, Nicola, Maggi, Fabrizio, Mancini, Nicasio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402759/
https://www.ncbi.nlm.nih.gov/pubmed/34452380
http://dx.doi.org/10.3390/v13081514
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author Castelli, Matteo
Baj, Andreina
Criscuolo, Elena
Ferrarese, Roberto
Diotti, Roberta A.
Sampaolo, Michela
Novazzi, Federica
Dalla Gasperina, Daniela
Focosi, Daniele
Ferrari, Davide
Locatelli, Massimo
Clementi, Massimo
Clementi, Nicola
Maggi, Fabrizio
Mancini, Nicasio
author_facet Castelli, Matteo
Baj, Andreina
Criscuolo, Elena
Ferrarese, Roberto
Diotti, Roberta A.
Sampaolo, Michela
Novazzi, Federica
Dalla Gasperina, Daniela
Focosi, Daniele
Ferrari, Davide
Locatelli, Massimo
Clementi, Massimo
Clementi, Nicola
Maggi, Fabrizio
Mancini, Nicasio
author_sort Castelli, Matteo
collection PubMed
description SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
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spelling pubmed-84027592021-08-29 Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy Castelli, Matteo Baj, Andreina Criscuolo, Elena Ferrarese, Roberto Diotti, Roberta A. Sampaolo, Michela Novazzi, Federica Dalla Gasperina, Daniela Focosi, Daniele Ferrari, Davide Locatelli, Massimo Clementi, Massimo Clementi, Nicola Maggi, Fabrizio Mancini, Nicasio Viruses Brief Report SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization. MDPI 2021-07-31 /pmc/articles/PMC8402759/ /pubmed/34452380 http://dx.doi.org/10.3390/v13081514 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Castelli, Matteo
Baj, Andreina
Criscuolo, Elena
Ferrarese, Roberto
Diotti, Roberta A.
Sampaolo, Michela
Novazzi, Federica
Dalla Gasperina, Daniela
Focosi, Daniele
Ferrari, Davide
Locatelli, Massimo
Clementi, Massimo
Clementi, Nicola
Maggi, Fabrizio
Mancini, Nicasio
Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
title Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
title_full Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
title_fullStr Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
title_full_unstemmed Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
title_short Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
title_sort characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402759/
https://www.ncbi.nlm.nih.gov/pubmed/34452380
http://dx.doi.org/10.3390/v13081514
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