Cargando…
Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats
Feline morbillivirus (FeMV) was isolated for the first time in 2012 with an association with chronic kidney disease (CKD) suggested. This study aimed at investigating in cats from southern Italy FeMV prevalence and risk factors for exposure to FeMV, including the relationship with CKD; sequencing am...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402783/ https://www.ncbi.nlm.nih.gov/pubmed/34452315 http://dx.doi.org/10.3390/v13081449 |
_version_ | 1783745873233051648 |
---|---|
author | Donato, Giulia Masucci, Marisa De Luca, Eliana Alibrandi, Angela De Majo, Massimo Berjaoui, Shadia Martino, Camillo Mangano, Cyndi Lorusso, Alessio Pennisi, Maria Grazia |
author_facet | Donato, Giulia Masucci, Marisa De Luca, Eliana Alibrandi, Angela De Majo, Massimo Berjaoui, Shadia Martino, Camillo Mangano, Cyndi Lorusso, Alessio Pennisi, Maria Grazia |
author_sort | Donato, Giulia |
collection | PubMed |
description | Feline morbillivirus (FeMV) was isolated for the first time in 2012 with an association with chronic kidney disease (CKD) suggested. This study aimed at investigating in cats from southern Italy FeMV prevalence and risk factors for exposure to FeMV, including the relationship with CKD; sequencing amplicons and analyzing phylogeny of PCR positive samples. Blood serum, K(3)EDTA blood and urine samples from 223 cats were investigated. Ten carcasses were also evaluated. FeMV RNA was detected in 2.4% (5/211) blood and 16.1% (36/223) urine samples. One carcass tested positive by qPCR(FeMV) from kidney, urinary bladder, and submandibular lymph nodes. Antibodies against FeMV were detected in 14.5% (28/193) cats. We followed up 27 cats (13 FeMV positive cats) and documented in some cases urine shedding after up to 360 days. Older and foundling cats and cats living in rescue catteries, were more frequently infected with FeMV. A significant correlation between FeMV and higher serum creatinine values or low urine specific gravity was found. FeMV positivity was significantly associated with retroviral infection, and the presence of some clinical signs apart from CKD clinicopathological markers. Our study highlights the possibility of a link between FeMV exposure and CKD and a general impairment of feline health. |
format | Online Article Text |
id | pubmed-8402783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84027832021-08-29 Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats Donato, Giulia Masucci, Marisa De Luca, Eliana Alibrandi, Angela De Majo, Massimo Berjaoui, Shadia Martino, Camillo Mangano, Cyndi Lorusso, Alessio Pennisi, Maria Grazia Viruses Article Feline morbillivirus (FeMV) was isolated for the first time in 2012 with an association with chronic kidney disease (CKD) suggested. This study aimed at investigating in cats from southern Italy FeMV prevalence and risk factors for exposure to FeMV, including the relationship with CKD; sequencing amplicons and analyzing phylogeny of PCR positive samples. Blood serum, K(3)EDTA blood and urine samples from 223 cats were investigated. Ten carcasses were also evaluated. FeMV RNA was detected in 2.4% (5/211) blood and 16.1% (36/223) urine samples. One carcass tested positive by qPCR(FeMV) from kidney, urinary bladder, and submandibular lymph nodes. Antibodies against FeMV were detected in 14.5% (28/193) cats. We followed up 27 cats (13 FeMV positive cats) and documented in some cases urine shedding after up to 360 days. Older and foundling cats and cats living in rescue catteries, were more frequently infected with FeMV. A significant correlation between FeMV and higher serum creatinine values or low urine specific gravity was found. FeMV positivity was significantly associated with retroviral infection, and the presence of some clinical signs apart from CKD clinicopathological markers. Our study highlights the possibility of a link between FeMV exposure and CKD and a general impairment of feline health. MDPI 2021-07-25 /pmc/articles/PMC8402783/ /pubmed/34452315 http://dx.doi.org/10.3390/v13081449 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Donato, Giulia Masucci, Marisa De Luca, Eliana Alibrandi, Angela De Majo, Massimo Berjaoui, Shadia Martino, Camillo Mangano, Cyndi Lorusso, Alessio Pennisi, Maria Grazia Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats |
title | Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats |
title_full | Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats |
title_fullStr | Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats |
title_full_unstemmed | Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats |
title_short | Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats |
title_sort | feline morbillivirus in southern italy: epidemiology, clinico-pathological features and phylogenetic analysis in cats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402783/ https://www.ncbi.nlm.nih.gov/pubmed/34452315 http://dx.doi.org/10.3390/v13081449 |
work_keys_str_mv | AT donatogiulia felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT masuccimarisa felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT delucaeliana felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT alibrandiangela felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT demajomassimo felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT berjaouishadia felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT martinocamillo felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT manganocyndi felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT lorussoalessio felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats AT pennisimariagrazia felinemorbillivirusinsouthernitalyepidemiologyclinicopathologicalfeaturesandphylogeneticanalysisincats |