Effect of Dickkopf-1 (Dkk-1) and SP600125, a JNK Inhibitor, on Wnt Signaling in Canine Prostate Cancer Growth and Bone Metastases

Human Dickkopf-1 (Dkk-1) upregulates a noncanonical Wnt/JNK pathway, resulting in osteoclast stimulation, cell proliferation, and epithelial-to-mesenchymal transition (EMT) of cancer cells. Ace-1-Dkk-1, a canine prostate cancer (PCa) cell line overexpressing Dkk-1, was used to investigate Wnt signal...

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Detalles Bibliográficos
Autores principales: Supsavhad, Wachiraphan, Hassan, Bardes B., Simmons, Jessica K., Dirksen, Wessel P., Elshafae, Said M., Kohart, Nicole A., Demirer, Aylin A., Rosol, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402794/
https://www.ncbi.nlm.nih.gov/pubmed/34437475
http://dx.doi.org/10.3390/vetsci8080153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402794/
https://www.ncbi.nlm.nih.gov/pubmed/34437475
http://dx.doi.org/10.3390/vetsci8080153

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