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Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)

Enterovirus D68 (EV-D68) has emerged as an agent of epidemic respiratory illness and acute flaccid myelitis in the paediatric population but data are lacking in adult patients. We performed a 4.5-year single-centre retrospective study of all patients who tested positive for EV-D68 and analysed full-...

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Autores principales: Duval, Maxime, Mirand, Audrey, Lesens, Olivier, Bay, Jacques-Olivier, Caillaud, Denis, Gallot, Denis, Lautrette, Alexandre, Montcouquiol, Sylvie, Schmidt, Jeannot, Egron, Carole, Jugie, Gwendoline, Bisseux, Maxime, Archimbaud, Christine, Lambert, Céline, Henquell, Cécile, Bailly, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402803/
https://www.ncbi.nlm.nih.gov/pubmed/34452471
http://dx.doi.org/10.3390/v13081607
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author Duval, Maxime
Mirand, Audrey
Lesens, Olivier
Bay, Jacques-Olivier
Caillaud, Denis
Gallot, Denis
Lautrette, Alexandre
Montcouquiol, Sylvie
Schmidt, Jeannot
Egron, Carole
Jugie, Gwendoline
Bisseux, Maxime
Archimbaud, Christine
Lambert, Céline
Henquell, Cécile
Bailly, Jean-Luc
author_facet Duval, Maxime
Mirand, Audrey
Lesens, Olivier
Bay, Jacques-Olivier
Caillaud, Denis
Gallot, Denis
Lautrette, Alexandre
Montcouquiol, Sylvie
Schmidt, Jeannot
Egron, Carole
Jugie, Gwendoline
Bisseux, Maxime
Archimbaud, Christine
Lambert, Céline
Henquell, Cécile
Bailly, Jean-Luc
author_sort Duval, Maxime
collection PubMed
description Enterovirus D68 (EV-D68) has emerged as an agent of epidemic respiratory illness and acute flaccid myelitis in the paediatric population but data are lacking in adult patients. We performed a 4.5-year single-centre retrospective study of all patients who tested positive for EV-D68 and analysed full-length EV-D68 genomes of the predominant clades B3 and D1. Between 1 June 2014, and 31 December 2018, 73 of the 11,365 patients investigated for respiratory pathogens tested positive for EV-D68, of whom 20 (27%) were adults (median age 53.7 years [IQR 34.0–65.7]) and 53 (73%) were children (median age 1.9 years [IQR 0.2–4.0]). The proportion of adults increased from 12% in 2014 to 48% in 2018 (p = 0.01). All adults had an underlying comorbidity factor, including chronic lung disease in 12 (60%), diabetes mellitus in six (30%), and chronic heart disease in five (25%). Clade D1 infected a higher proportion of adults than clades B3 and B2 (p = 0.001). Clade D1 was more divergent than clade B3: 5 of 19 amino acid changes in the capsid proteins were located in putative antigenic sites. Adult patients with underlying conditions are more likely to present with severe complications associated with EV-D68, notably the emergent clade D1.
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spelling pubmed-84028032021-08-29 Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) Duval, Maxime Mirand, Audrey Lesens, Olivier Bay, Jacques-Olivier Caillaud, Denis Gallot, Denis Lautrette, Alexandre Montcouquiol, Sylvie Schmidt, Jeannot Egron, Carole Jugie, Gwendoline Bisseux, Maxime Archimbaud, Christine Lambert, Céline Henquell, Cécile Bailly, Jean-Luc Viruses Article Enterovirus D68 (EV-D68) has emerged as an agent of epidemic respiratory illness and acute flaccid myelitis in the paediatric population but data are lacking in adult patients. We performed a 4.5-year single-centre retrospective study of all patients who tested positive for EV-D68 and analysed full-length EV-D68 genomes of the predominant clades B3 and D1. Between 1 June 2014, and 31 December 2018, 73 of the 11,365 patients investigated for respiratory pathogens tested positive for EV-D68, of whom 20 (27%) were adults (median age 53.7 years [IQR 34.0–65.7]) and 53 (73%) were children (median age 1.9 years [IQR 0.2–4.0]). The proportion of adults increased from 12% in 2014 to 48% in 2018 (p = 0.01). All adults had an underlying comorbidity factor, including chronic lung disease in 12 (60%), diabetes mellitus in six (30%), and chronic heart disease in five (25%). Clade D1 infected a higher proportion of adults than clades B3 and B2 (p = 0.001). Clade D1 was more divergent than clade B3: 5 of 19 amino acid changes in the capsid proteins were located in putative antigenic sites. Adult patients with underlying conditions are more likely to present with severe complications associated with EV-D68, notably the emergent clade D1. MDPI 2021-08-13 /pmc/articles/PMC8402803/ /pubmed/34452471 http://dx.doi.org/10.3390/v13081607 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duval, Maxime
Mirand, Audrey
Lesens, Olivier
Bay, Jacques-Olivier
Caillaud, Denis
Gallot, Denis
Lautrette, Alexandre
Montcouquiol, Sylvie
Schmidt, Jeannot
Egron, Carole
Jugie, Gwendoline
Bisseux, Maxime
Archimbaud, Christine
Lambert, Céline
Henquell, Cécile
Bailly, Jean-Luc
Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)
title Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)
title_full Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)
title_fullStr Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)
title_full_unstemmed Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)
title_short Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)
title_sort retrospective study of the upsurge of enterovirus d68 clade d1 among adults (2014–2018)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402803/
https://www.ncbi.nlm.nih.gov/pubmed/34452471
http://dx.doi.org/10.3390/v13081607
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