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Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018)
Enterovirus D68 (EV-D68) has emerged as an agent of epidemic respiratory illness and acute flaccid myelitis in the paediatric population but data are lacking in adult patients. We performed a 4.5-year single-centre retrospective study of all patients who tested positive for EV-D68 and analysed full-...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402803/ https://www.ncbi.nlm.nih.gov/pubmed/34452471 http://dx.doi.org/10.3390/v13081607 |
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author | Duval, Maxime Mirand, Audrey Lesens, Olivier Bay, Jacques-Olivier Caillaud, Denis Gallot, Denis Lautrette, Alexandre Montcouquiol, Sylvie Schmidt, Jeannot Egron, Carole Jugie, Gwendoline Bisseux, Maxime Archimbaud, Christine Lambert, Céline Henquell, Cécile Bailly, Jean-Luc |
author_facet | Duval, Maxime Mirand, Audrey Lesens, Olivier Bay, Jacques-Olivier Caillaud, Denis Gallot, Denis Lautrette, Alexandre Montcouquiol, Sylvie Schmidt, Jeannot Egron, Carole Jugie, Gwendoline Bisseux, Maxime Archimbaud, Christine Lambert, Céline Henquell, Cécile Bailly, Jean-Luc |
author_sort | Duval, Maxime |
collection | PubMed |
description | Enterovirus D68 (EV-D68) has emerged as an agent of epidemic respiratory illness and acute flaccid myelitis in the paediatric population but data are lacking in adult patients. We performed a 4.5-year single-centre retrospective study of all patients who tested positive for EV-D68 and analysed full-length EV-D68 genomes of the predominant clades B3 and D1. Between 1 June 2014, and 31 December 2018, 73 of the 11,365 patients investigated for respiratory pathogens tested positive for EV-D68, of whom 20 (27%) were adults (median age 53.7 years [IQR 34.0–65.7]) and 53 (73%) were children (median age 1.9 years [IQR 0.2–4.0]). The proportion of adults increased from 12% in 2014 to 48% in 2018 (p = 0.01). All adults had an underlying comorbidity factor, including chronic lung disease in 12 (60%), diabetes mellitus in six (30%), and chronic heart disease in five (25%). Clade D1 infected a higher proportion of adults than clades B3 and B2 (p = 0.001). Clade D1 was more divergent than clade B3: 5 of 19 amino acid changes in the capsid proteins were located in putative antigenic sites. Adult patients with underlying conditions are more likely to present with severe complications associated with EV-D68, notably the emergent clade D1. |
format | Online Article Text |
id | pubmed-8402803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84028032021-08-29 Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) Duval, Maxime Mirand, Audrey Lesens, Olivier Bay, Jacques-Olivier Caillaud, Denis Gallot, Denis Lautrette, Alexandre Montcouquiol, Sylvie Schmidt, Jeannot Egron, Carole Jugie, Gwendoline Bisseux, Maxime Archimbaud, Christine Lambert, Céline Henquell, Cécile Bailly, Jean-Luc Viruses Article Enterovirus D68 (EV-D68) has emerged as an agent of epidemic respiratory illness and acute flaccid myelitis in the paediatric population but data are lacking in adult patients. We performed a 4.5-year single-centre retrospective study of all patients who tested positive for EV-D68 and analysed full-length EV-D68 genomes of the predominant clades B3 and D1. Between 1 June 2014, and 31 December 2018, 73 of the 11,365 patients investigated for respiratory pathogens tested positive for EV-D68, of whom 20 (27%) were adults (median age 53.7 years [IQR 34.0–65.7]) and 53 (73%) were children (median age 1.9 years [IQR 0.2–4.0]). The proportion of adults increased from 12% in 2014 to 48% in 2018 (p = 0.01). All adults had an underlying comorbidity factor, including chronic lung disease in 12 (60%), diabetes mellitus in six (30%), and chronic heart disease in five (25%). Clade D1 infected a higher proportion of adults than clades B3 and B2 (p = 0.001). Clade D1 was more divergent than clade B3: 5 of 19 amino acid changes in the capsid proteins were located in putative antigenic sites. Adult patients with underlying conditions are more likely to present with severe complications associated with EV-D68, notably the emergent clade D1. MDPI 2021-08-13 /pmc/articles/PMC8402803/ /pubmed/34452471 http://dx.doi.org/10.3390/v13081607 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Duval, Maxime Mirand, Audrey Lesens, Olivier Bay, Jacques-Olivier Caillaud, Denis Gallot, Denis Lautrette, Alexandre Montcouquiol, Sylvie Schmidt, Jeannot Egron, Carole Jugie, Gwendoline Bisseux, Maxime Archimbaud, Christine Lambert, Céline Henquell, Cécile Bailly, Jean-Luc Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) |
title | Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) |
title_full | Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) |
title_fullStr | Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) |
title_full_unstemmed | Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) |
title_short | Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014–2018) |
title_sort | retrospective study of the upsurge of enterovirus d68 clade d1 among adults (2014–2018) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402803/ https://www.ncbi.nlm.nih.gov/pubmed/34452471 http://dx.doi.org/10.3390/v13081607 |
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