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Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany
Here, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority identified in laboratories from a single German state (Baden-Wuerttemberg, n = 572...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402818/ https://www.ncbi.nlm.nih.gov/pubmed/34452356 http://dx.doi.org/10.3390/v13081491 |
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author | Calvignac-Spencer, Sébastien Budt, Matthias Huska, Matthew Richard, Hugues Leipold, Luca Grabenhenrich, Linus Semmler, Torsten von Kleist, Max Kröger, Stefan Wolff, Thorsten Hölzer, Martin |
author_facet | Calvignac-Spencer, Sébastien Budt, Matthias Huska, Matthew Richard, Hugues Leipold, Luca Grabenhenrich, Linus Semmler, Torsten von Kleist, Max Kröger, Stefan Wolff, Thorsten Hölzer, Martin |
author_sort | Calvignac-Spencer, Sébastien |
collection | PubMed |
description | Here, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority identified in laboratories from a single German state (Baden-Wuerttemberg, n = 572; 80.5%). Baden-Wuerttemberg is located near the border with France, from where most A.27 sequences were entered into public databases until May 2021. The first appearance of this lineage based on sequencing in a laboratory in Baden-Wuerttemberg can be dated to early January ’21. From then on, the relative abundance of A.27 increased until the end of February but has since declined—meanwhile, the abundance of B.1.1.7 increased in the region. The A.27 lineage shows a mutational pattern typical of VOIs/VOCs, including an accumulation of amino acid substitutions in the Spike glycoprotein. Among those, L18F, L452R and N501Y are located in the epitope regions of the N-terminal- (NTD) or receptor binding domain (RBD) and have been suggested to result in immune escape and higher transmissibility. In addition, A.27 does not show the D614G mutation typical for all VOIs/VOCs from the B lineage. Overall, A.27 should continue to be monitored nationally and internationally, even though the observed trend in Germany was initially displaced by B.1.1.7 (Alpha), while now B.1.617.2 (Delta) is on the rise. |
format | Online Article Text |
id | pubmed-8402818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84028182021-08-29 Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany Calvignac-Spencer, Sébastien Budt, Matthias Huska, Matthew Richard, Hugues Leipold, Luca Grabenhenrich, Linus Semmler, Torsten von Kleist, Max Kröger, Stefan Wolff, Thorsten Hölzer, Martin Viruses Article Here, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority identified in laboratories from a single German state (Baden-Wuerttemberg, n = 572; 80.5%). Baden-Wuerttemberg is located near the border with France, from where most A.27 sequences were entered into public databases until May 2021. The first appearance of this lineage based on sequencing in a laboratory in Baden-Wuerttemberg can be dated to early January ’21. From then on, the relative abundance of A.27 increased until the end of February but has since declined—meanwhile, the abundance of B.1.1.7 increased in the region. The A.27 lineage shows a mutational pattern typical of VOIs/VOCs, including an accumulation of amino acid substitutions in the Spike glycoprotein. Among those, L18F, L452R and N501Y are located in the epitope regions of the N-terminal- (NTD) or receptor binding domain (RBD) and have been suggested to result in immune escape and higher transmissibility. In addition, A.27 does not show the D614G mutation typical for all VOIs/VOCs from the B lineage. Overall, A.27 should continue to be monitored nationally and internationally, even though the observed trend in Germany was initially displaced by B.1.1.7 (Alpha), while now B.1.617.2 (Delta) is on the rise. MDPI 2021-07-29 /pmc/articles/PMC8402818/ /pubmed/34452356 http://dx.doi.org/10.3390/v13081491 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Calvignac-Spencer, Sébastien Budt, Matthias Huska, Matthew Richard, Hugues Leipold, Luca Grabenhenrich, Linus Semmler, Torsten von Kleist, Max Kröger, Stefan Wolff, Thorsten Hölzer, Martin Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany |
title | Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany |
title_full | Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany |
title_fullStr | Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany |
title_full_unstemmed | Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany |
title_short | Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany |
title_sort | rise and fall of sars-cov-2 lineage a.27 in germany |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402818/ https://www.ncbi.nlm.nih.gov/pubmed/34452356 http://dx.doi.org/10.3390/v13081491 |
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