Cargando…

Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany

Here, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority identified in laboratories from a single German state (Baden-Wuerttemberg, n = 572...

Descripción completa

Detalles Bibliográficos
Autores principales: Calvignac-Spencer, Sébastien, Budt, Matthias, Huska, Matthew, Richard, Hugues, Leipold, Luca, Grabenhenrich, Linus, Semmler, Torsten, von Kleist, Max, Kröger, Stefan, Wolff, Thorsten, Hölzer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402818/
https://www.ncbi.nlm.nih.gov/pubmed/34452356
http://dx.doi.org/10.3390/v13081491
_version_ 1783745882581106688
author Calvignac-Spencer, Sébastien
Budt, Matthias
Huska, Matthew
Richard, Hugues
Leipold, Luca
Grabenhenrich, Linus
Semmler, Torsten
von Kleist, Max
Kröger, Stefan
Wolff, Thorsten
Hölzer, Martin
author_facet Calvignac-Spencer, Sébastien
Budt, Matthias
Huska, Matthew
Richard, Hugues
Leipold, Luca
Grabenhenrich, Linus
Semmler, Torsten
von Kleist, Max
Kröger, Stefan
Wolff, Thorsten
Hölzer, Martin
author_sort Calvignac-Spencer, Sébastien
collection PubMed
description Here, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority identified in laboratories from a single German state (Baden-Wuerttemberg, n = 572; 80.5%). Baden-Wuerttemberg is located near the border with France, from where most A.27 sequences were entered into public databases until May 2021. The first appearance of this lineage based on sequencing in a laboratory in Baden-Wuerttemberg can be dated to early January ’21. From then on, the relative abundance of A.27 increased until the end of February but has since declined—meanwhile, the abundance of B.1.1.7 increased in the region. The A.27 lineage shows a mutational pattern typical of VOIs/VOCs, including an accumulation of amino acid substitutions in the Spike glycoprotein. Among those, L18F, L452R and N501Y are located in the epitope regions of the N-terminal- (NTD) or receptor binding domain (RBD) and have been suggested to result in immune escape and higher transmissibility. In addition, A.27 does not show the D614G mutation typical for all VOIs/VOCs from the B lineage. Overall, A.27 should continue to be monitored nationally and internationally, even though the observed trend in Germany was initially displaced by B.1.1.7 (Alpha), while now B.1.617.2 (Delta) is on the rise.
format Online
Article
Text
id pubmed-8402818
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84028182021-08-29 Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany Calvignac-Spencer, Sébastien Budt, Matthias Huska, Matthew Richard, Hugues Leipold, Luca Grabenhenrich, Linus Semmler, Torsten von Kleist, Max Kröger, Stefan Wolff, Thorsten Hölzer, Martin Viruses Article Here, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority identified in laboratories from a single German state (Baden-Wuerttemberg, n = 572; 80.5%). Baden-Wuerttemberg is located near the border with France, from where most A.27 sequences were entered into public databases until May 2021. The first appearance of this lineage based on sequencing in a laboratory in Baden-Wuerttemberg can be dated to early January ’21. From then on, the relative abundance of A.27 increased until the end of February but has since declined—meanwhile, the abundance of B.1.1.7 increased in the region. The A.27 lineage shows a mutational pattern typical of VOIs/VOCs, including an accumulation of amino acid substitutions in the Spike glycoprotein. Among those, L18F, L452R and N501Y are located in the epitope regions of the N-terminal- (NTD) or receptor binding domain (RBD) and have been suggested to result in immune escape and higher transmissibility. In addition, A.27 does not show the D614G mutation typical for all VOIs/VOCs from the B lineage. Overall, A.27 should continue to be monitored nationally and internationally, even though the observed trend in Germany was initially displaced by B.1.1.7 (Alpha), while now B.1.617.2 (Delta) is on the rise. MDPI 2021-07-29 /pmc/articles/PMC8402818/ /pubmed/34452356 http://dx.doi.org/10.3390/v13081491 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Calvignac-Spencer, Sébastien
Budt, Matthias
Huska, Matthew
Richard, Hugues
Leipold, Luca
Grabenhenrich, Linus
Semmler, Torsten
von Kleist, Max
Kröger, Stefan
Wolff, Thorsten
Hölzer, Martin
Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany
title Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany
title_full Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany
title_fullStr Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany
title_full_unstemmed Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany
title_short Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany
title_sort rise and fall of sars-cov-2 lineage a.27 in germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402818/
https://www.ncbi.nlm.nih.gov/pubmed/34452356
http://dx.doi.org/10.3390/v13081491
work_keys_str_mv AT calvignacspencersebastien riseandfallofsarscov2lineagea27ingermany
AT budtmatthias riseandfallofsarscov2lineagea27ingermany
AT huskamatthew riseandfallofsarscov2lineagea27ingermany
AT richardhugues riseandfallofsarscov2lineagea27ingermany
AT leipoldluca riseandfallofsarscov2lineagea27ingermany
AT grabenhenrichlinus riseandfallofsarscov2lineagea27ingermany
AT semmlertorsten riseandfallofsarscov2lineagea27ingermany
AT vonkleistmax riseandfallofsarscov2lineagea27ingermany
AT krogerstefan riseandfallofsarscov2lineagea27ingermany
AT wolffthorsten riseandfallofsarscov2lineagea27ingermany
AT holzermartin riseandfallofsarscov2lineagea27ingermany