Coagulopathy in Acute Puumala Hantavirus Infection

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Mult...

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Detalles Bibliográficos
Autores principales: Koskela, Sirpa, Mäkelä, Satu, Strandin, Tomas, Vaheri, Antti, Outinen, Tuula, Joutsi-Korhonen, Lotta, Pörsti, Ilkka, Mustonen, Jukka, Laine, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402851/
https://www.ncbi.nlm.nih.gov/pubmed/34452419
http://dx.doi.org/10.3390/v13081553
Descripción
Sumario:Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

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