Coagulopathy in Acute Puumala Hantavirus Infection

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Mult...

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Autores principales: Koskela, Sirpa, Mäkelä, Satu, Strandin, Tomas, Vaheri, Antti, Outinen, Tuula, Joutsi-Korhonen, Lotta, Pörsti, Ilkka, Mustonen, Jukka, Laine, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402851/
https://www.ncbi.nlm.nih.gov/pubmed/34452419
http://dx.doi.org/10.3390/v13081553
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author Koskela, Sirpa
Mäkelä, Satu
Strandin, Tomas
Vaheri, Antti
Outinen, Tuula
Joutsi-Korhonen, Lotta
Pörsti, Ilkka
Mustonen, Jukka
Laine, Outi
author_facet Koskela, Sirpa
Mäkelä, Satu
Strandin, Tomas
Vaheri, Antti
Outinen, Tuula
Joutsi-Korhonen, Lotta
Pörsti, Ilkka
Mustonen, Jukka
Laine, Outi
author_sort Koskela, Sirpa
collection PubMed
description Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.
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spelling pubmed-84028512021-08-29 Coagulopathy in Acute Puumala Hantavirus Infection Koskela, Sirpa Mäkelä, Satu Strandin, Tomas Vaheri, Antti Outinen, Tuula Joutsi-Korhonen, Lotta Pörsti, Ilkka Mustonen, Jukka Laine, Outi Viruses Review Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis. MDPI 2021-08-06 /pmc/articles/PMC8402851/ /pubmed/34452419 http://dx.doi.org/10.3390/v13081553 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koskela, Sirpa
Mäkelä, Satu
Strandin, Tomas
Vaheri, Antti
Outinen, Tuula
Joutsi-Korhonen, Lotta
Pörsti, Ilkka
Mustonen, Jukka
Laine, Outi
Coagulopathy in Acute Puumala Hantavirus Infection
title Coagulopathy in Acute Puumala Hantavirus Infection
title_full Coagulopathy in Acute Puumala Hantavirus Infection
title_fullStr Coagulopathy in Acute Puumala Hantavirus Infection
title_full_unstemmed Coagulopathy in Acute Puumala Hantavirus Infection
title_short Coagulopathy in Acute Puumala Hantavirus Infection
title_sort coagulopathy in acute puumala hantavirus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402851/
https://www.ncbi.nlm.nih.gov/pubmed/34452419
http://dx.doi.org/10.3390/v13081553
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