Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma

Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on...

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Detalles Bibliográficos
Autores principales: Gameiro, Andreia, Urbano, Ana Catarina, Ferreira, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402877/
https://www.ncbi.nlm.nih.gov/pubmed/34437486
http://dx.doi.org/10.3390/vetsci8080164
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author Gameiro, Andreia
Urbano, Ana Catarina
Ferreira, Fernando
author_facet Gameiro, Andreia
Urbano, Ana Catarina
Ferreira, Fernando
author_sort Gameiro, Andreia
collection PubMed
description Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers, thus reinforcing the utility of the cat as a cancer model. In this article, we review the current knowledge on FMC pathogenesis, biomarkers, and prognosis factors and offer new insights into novel therapeutic options for HER2-positive and triple-negative FMC subtypes.
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spelling pubmed-84028772021-08-29 Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma Gameiro, Andreia Urbano, Ana Catarina Ferreira, Fernando Vet Sci Review Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers, thus reinforcing the utility of the cat as a cancer model. In this article, we review the current knowledge on FMC pathogenesis, biomarkers, and prognosis factors and offer new insights into novel therapeutic options for HER2-positive and triple-negative FMC subtypes. MDPI 2021-08-11 /pmc/articles/PMC8402877/ /pubmed/34437486 http://dx.doi.org/10.3390/vetsci8080164 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gameiro, Andreia
Urbano, Ana Catarina
Ferreira, Fernando
Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma
title Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma
title_full Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma
title_fullStr Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma
title_full_unstemmed Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma
title_short Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma
title_sort emerging biomarkers and targeted therapies in feline mammary carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402877/
https://www.ncbi.nlm.nih.gov/pubmed/34437486
http://dx.doi.org/10.3390/vetsci8080164
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