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From bench to bar side: Evaluating the red wine storage lesion
Vitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resulting storage lesion has particular significance in perioperative medicine. We hypothesized that, in contrast, aging rathe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402936/ https://www.ncbi.nlm.nih.gov/pubmed/34522781 http://dx.doi.org/10.1515/biol-2021-0089 |
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author | Klaschik, Sven Ellerkmann, Richard K. Gehlen, Jennifer Frede, Stilla Hilbert, Tobias |
author_facet | Klaschik, Sven Ellerkmann, Richard K. Gehlen, Jennifer Frede, Stilla Hilbert, Tobias |
author_sort | Klaschik, Sven |
collection | PubMed |
description | Vitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resulting storage lesion has particular significance in perioperative medicine. We hypothesized that, in contrast, aging rather improves the properties of red wine in several ways. A translational approach, including (I) in vitro experiments, (II) a randomized, blinded crossover trial of acute clinical effects, and (III) a standardized red wine blind tasting was used. Three monovarietal wines (Cabernet Sauvignon, Chianti, Shiraz) in three different vintages (range 2004–2016), each 5 years different, were assessed. Assessments were performed at a German university hospital (I, II) and on a garden terrace during a mild summer evening (III). Young wines induced cell stress and damage while significantly reducing cytoprotective proteins in HepG2 hepatoma cells. Sympathetic activity and multitasking skills were altered depending on wines’ ages. Hangovers tended to be aggravated by young red wine. Aged variants performed better in terms of aroma and overall quality but worse in optical appearance. We found no evidence for a red wine storage lesion. However, we plead for consensus-based guidelines for proper storage, as it is common in clinical medicine. |
format | Online Article Text |
id | pubmed-8402936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-84029362021-09-13 From bench to bar side: Evaluating the red wine storage lesion Klaschik, Sven Ellerkmann, Richard K. Gehlen, Jennifer Frede, Stilla Hilbert, Tobias Open Life Sci Research Article Vitally essential red fluids like packed cells and red wine are seriously influenced in quality when stored over prolonged periods. In the case of red cell concentrates, the resulting storage lesion has particular significance in perioperative medicine. We hypothesized that, in contrast, aging rather improves the properties of red wine in several ways. A translational approach, including (I) in vitro experiments, (II) a randomized, blinded crossover trial of acute clinical effects, and (III) a standardized red wine blind tasting was used. Three monovarietal wines (Cabernet Sauvignon, Chianti, Shiraz) in three different vintages (range 2004–2016), each 5 years different, were assessed. Assessments were performed at a German university hospital (I, II) and on a garden terrace during a mild summer evening (III). Young wines induced cell stress and damage while significantly reducing cytoprotective proteins in HepG2 hepatoma cells. Sympathetic activity and multitasking skills were altered depending on wines’ ages. Hangovers tended to be aggravated by young red wine. Aged variants performed better in terms of aroma and overall quality but worse in optical appearance. We found no evidence for a red wine storage lesion. However, we plead for consensus-based guidelines for proper storage, as it is common in clinical medicine. De Gruyter 2021-08-28 /pmc/articles/PMC8402936/ /pubmed/34522781 http://dx.doi.org/10.1515/biol-2021-0089 Text en © 2021 Sven Klaschik et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article Klaschik, Sven Ellerkmann, Richard K. Gehlen, Jennifer Frede, Stilla Hilbert, Tobias From bench to bar side: Evaluating the red wine storage lesion |
title | From bench to bar side: Evaluating the red wine storage lesion
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title_full | From bench to bar side: Evaluating the red wine storage lesion
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title_fullStr | From bench to bar side: Evaluating the red wine storage lesion
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title_full_unstemmed | From bench to bar side: Evaluating the red wine storage lesion
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title_short | From bench to bar side: Evaluating the red wine storage lesion
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title_sort | from bench to bar side: evaluating the red wine storage lesion |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402936/ https://www.ncbi.nlm.nih.gov/pubmed/34522781 http://dx.doi.org/10.1515/biol-2021-0089 |
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