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Wells Syndrome Successfully Treated with Tripterygium Glycosides
Wells syndrome (WS), also known as eosinophilic cellulitis, is a rare inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques. The first line treatment options for WS are topical or systemic corticosteroids, however, the development of side effects o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402950/ https://www.ncbi.nlm.nih.gov/pubmed/34466011 http://dx.doi.org/10.2147/CCID.S328578 |
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author | Lu, Jiejie Wu, Weiwei Zhang, Ming Wang, Ping Niu, Mu Yang, Xianxu |
author_facet | Lu, Jiejie Wu, Weiwei Zhang, Ming Wang, Ping Niu, Mu Yang, Xianxu |
author_sort | Lu, Jiejie |
collection | PubMed |
description | Wells syndrome (WS), also known as eosinophilic cellulitis, is a rare inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques. The first line treatment options for WS are topical or systemic corticosteroids, however, the development of side effects of systemic corticosteroids usually led to a switch to the second line therapy. Here, we reported a rare case of facial Wells syndrome misdiagnosed with bacterial cellulitis. A 26-year-old female presented with a one-week history of erythematous, edematous and blushing plaques partially covered by bullae. A skin biopsy revealed diffuse infiltration of eosinophils in the entire dermis and “flame figures” compatible with WS. Initially, the patient was successfully treated with methylprednisolone. However, three month later, the disease relapsed. Because of weight gain and centripetal obesity, the patient refused to oral administration of methylprednisolone. Traditional Chinese Medicine tripterygium glycosides (TG) 60mg/day was prescribed and the lesions completely resolved after 4 weeks without any recurrence. Our case suggests that tripterygium glycosides may be a safe and effective treatment option for Wells syndrome. |
format | Online Article Text |
id | pubmed-8402950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-84029502021-08-30 Wells Syndrome Successfully Treated with Tripterygium Glycosides Lu, Jiejie Wu, Weiwei Zhang, Ming Wang, Ping Niu, Mu Yang, Xianxu Clin Cosmet Investig Dermatol Case Report Wells syndrome (WS), also known as eosinophilic cellulitis, is a rare inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques. The first line treatment options for WS are topical or systemic corticosteroids, however, the development of side effects of systemic corticosteroids usually led to a switch to the second line therapy. Here, we reported a rare case of facial Wells syndrome misdiagnosed with bacterial cellulitis. A 26-year-old female presented with a one-week history of erythematous, edematous and blushing plaques partially covered by bullae. A skin biopsy revealed diffuse infiltration of eosinophils in the entire dermis and “flame figures” compatible with WS. Initially, the patient was successfully treated with methylprednisolone. However, three month later, the disease relapsed. Because of weight gain and centripetal obesity, the patient refused to oral administration of methylprednisolone. Traditional Chinese Medicine tripterygium glycosides (TG) 60mg/day was prescribed and the lesions completely resolved after 4 weeks without any recurrence. Our case suggests that tripterygium glycosides may be a safe and effective treatment option for Wells syndrome. Dove 2021-08-24 /pmc/articles/PMC8402950/ /pubmed/34466011 http://dx.doi.org/10.2147/CCID.S328578 Text en © 2021 Lu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Case Report Lu, Jiejie Wu, Weiwei Zhang, Ming Wang, Ping Niu, Mu Yang, Xianxu Wells Syndrome Successfully Treated with Tripterygium Glycosides |
title | Wells Syndrome Successfully Treated with Tripterygium Glycosides |
title_full | Wells Syndrome Successfully Treated with Tripterygium Glycosides |
title_fullStr | Wells Syndrome Successfully Treated with Tripterygium Glycosides |
title_full_unstemmed | Wells Syndrome Successfully Treated with Tripterygium Glycosides |
title_short | Wells Syndrome Successfully Treated with Tripterygium Glycosides |
title_sort | wells syndrome successfully treated with tripterygium glycosides |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402950/ https://www.ncbi.nlm.nih.gov/pubmed/34466011 http://dx.doi.org/10.2147/CCID.S328578 |
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