Polyketone metabolites isolated from Rhodiola tibetica endohytic fungus Alternaria sp. HJT-Y7 and their SARS-CoV-2 virus inhibitory activitives

Six new polyketone metabolites, compounds (1–6) and seven known polyketone compounds (7–13) were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. The structural elucidation of five new polyketone metabolites were elucidated on the basis of spectroscopic including 2D NMR and HRMS and spectrometric analysis. Inhibition rate evaluation revealed that compounds 1(EC(50) = 0.02 mM), 3(EC(50) = 0.3 mM), 6(EC(50) = 0.07 mM), 8(EC(50) = 0.1 mM) and 9(EC(50) = 0.04 mM) had inhibitory effect on the SARS-CoV-2 virus.