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Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review

INTRODUCTION: Aspirin appeared as a medicine to deal with aches and inflammation, but due to its antiplatelet properties, it has evolved into a drug mainly used to avert cardiovascular disease. Regardless of its therapeutic uses, the limiting aspect for aspirin use has been its affiliation with gast...

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Autores principales: Kedir, Hanan Muzeyin, Sisay, Eskinder Ayalew, Abiye, Alfoalem Araba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403009/
https://www.ncbi.nlm.nih.gov/pubmed/34466020
http://dx.doi.org/10.2147/IJGM.S326929
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author Kedir, Hanan Muzeyin
Sisay, Eskinder Ayalew
Abiye, Alfoalem Araba
author_facet Kedir, Hanan Muzeyin
Sisay, Eskinder Ayalew
Abiye, Alfoalem Araba
author_sort Kedir, Hanan Muzeyin
collection PubMed
description INTRODUCTION: Aspirin appeared as a medicine to deal with aches and inflammation, but due to its antiplatelet properties, it has evolved into a drug mainly used to avert cardiovascular disease. Regardless of its therapeutic uses, the limiting aspect for aspirin use has been its affiliation with gastrointestinal (GI) toxicity, classifying from acute mucosal damage to GI problems and death. OBJECTIVE: The aim of this systematic review is to address the question regarding the ECA effect on the gastric mucosa. METHODS: A systematic search of the literature was conducted in the PubMed electronic databases from April 10th to April 23rd, 2020. Eligibility has been set, and based on those criteria, initially a total of 637 results were obtained, from these 58 of them were not written in English. Then, 168 articles which were free from duplication were screened and all the included articles were RCTs published after 2000. Based on these, final number of articles included on this review was 6. RESULTS: Data were obtained from 6 published articles which reported on 15,621 participants. The reports were from 3 different countries. Most of the studies revealed that enteric-coated aspirin (ECA) treatment was not an effective mechanism against GI protection. ECA administration with omeprazole can hugely reduce the incidence of endoscopic GI damage compared to the impact of ECA used alone. Even short-term administration of a low dose of ECA was significantly associated with an apparent small bowel injury. CONCLUSION: ECA treatment is not an effective mechanism against GI protection, and it is highly associated with small bowel injury. So the coating does not reduce risk of GI complications.
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spelling pubmed-84030092021-08-30 Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review Kedir, Hanan Muzeyin Sisay, Eskinder Ayalew Abiye, Alfoalem Araba Int J Gen Med Review INTRODUCTION: Aspirin appeared as a medicine to deal with aches and inflammation, but due to its antiplatelet properties, it has evolved into a drug mainly used to avert cardiovascular disease. Regardless of its therapeutic uses, the limiting aspect for aspirin use has been its affiliation with gastrointestinal (GI) toxicity, classifying from acute mucosal damage to GI problems and death. OBJECTIVE: The aim of this systematic review is to address the question regarding the ECA effect on the gastric mucosa. METHODS: A systematic search of the literature was conducted in the PubMed electronic databases from April 10th to April 23rd, 2020. Eligibility has been set, and based on those criteria, initially a total of 637 results were obtained, from these 58 of them were not written in English. Then, 168 articles which were free from duplication were screened and all the included articles were RCTs published after 2000. Based on these, final number of articles included on this review was 6. RESULTS: Data were obtained from 6 published articles which reported on 15,621 participants. The reports were from 3 different countries. Most of the studies revealed that enteric-coated aspirin (ECA) treatment was not an effective mechanism against GI protection. ECA administration with omeprazole can hugely reduce the incidence of endoscopic GI damage compared to the impact of ECA used alone. Even short-term administration of a low dose of ECA was significantly associated with an apparent small bowel injury. CONCLUSION: ECA treatment is not an effective mechanism against GI protection, and it is highly associated with small bowel injury. So the coating does not reduce risk of GI complications. Dove 2021-08-24 /pmc/articles/PMC8403009/ /pubmed/34466020 http://dx.doi.org/10.2147/IJGM.S326929 Text en © 2021 Kedir et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Kedir, Hanan Muzeyin
Sisay, Eskinder Ayalew
Abiye, Alfoalem Araba
Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
title Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
title_full Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
title_fullStr Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
title_full_unstemmed Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
title_short Enteric-Coated Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
title_sort enteric-coated aspirin and the risk of gastrointestinal side effects: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403009/
https://www.ncbi.nlm.nih.gov/pubmed/34466020
http://dx.doi.org/10.2147/IJGM.S326929
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