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Molecular Targets of Ferroptosis in Hepatocellular Carcinoma

Ferroptosis is a special form of regulatory cell death caused by the accumulation of intracellular iron and lipid peroxidation. Here, we summarize the research progress on ferroptosis in hepatocellular carcinoma (HCC), trace the development of the concept of ferroptosis and its key regulatory factor...

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Detalles Bibliográficos
Autores principales: Liao, Hao, Shi, Juanyi, Wen, Kai, Lin, Jianhong, Liu, Qinghua, Shi, Bingchao, Yan, Yongcong, Xiao, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403010/
https://www.ncbi.nlm.nih.gov/pubmed/34466409
http://dx.doi.org/10.2147/JHC.S325593
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author Liao, Hao
Shi, Juanyi
Wen, Kai
Lin, Jianhong
Liu, Qinghua
Shi, Bingchao
Yan, Yongcong
Xiao, Zhiyu
author_facet Liao, Hao
Shi, Juanyi
Wen, Kai
Lin, Jianhong
Liu, Qinghua
Shi, Bingchao
Yan, Yongcong
Xiao, Zhiyu
author_sort Liao, Hao
collection PubMed
description Ferroptosis is a special form of regulatory cell death caused by the accumulation of intracellular iron and lipid peroxidation. Here, we summarize the research progress on ferroptosis in hepatocellular carcinoma (HCC), trace the development of the concept of ferroptosis and its key regulatory factors, and discuss the application value of ferroptosis in the treatment of HCC from different perspectives. We believe that exploring the relationship between ferroptosis and HCC and clarifying the metabolism and expression of ferroptosis-specific genes and molecules will accelerate the development of novel ferroptosis-related molecules as HCC markers and therapeutic targets. We hope to provide a theoretical basis for better diagnosis and treatment to effectively improve the prognosis of patients with HCC.
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spelling pubmed-84030102021-08-30 Molecular Targets of Ferroptosis in Hepatocellular Carcinoma Liao, Hao Shi, Juanyi Wen, Kai Lin, Jianhong Liu, Qinghua Shi, Bingchao Yan, Yongcong Xiao, Zhiyu J Hepatocell Carcinoma Review Ferroptosis is a special form of regulatory cell death caused by the accumulation of intracellular iron and lipid peroxidation. Here, we summarize the research progress on ferroptosis in hepatocellular carcinoma (HCC), trace the development of the concept of ferroptosis and its key regulatory factors, and discuss the application value of ferroptosis in the treatment of HCC from different perspectives. We believe that exploring the relationship between ferroptosis and HCC and clarifying the metabolism and expression of ferroptosis-specific genes and molecules will accelerate the development of novel ferroptosis-related molecules as HCC markers and therapeutic targets. We hope to provide a theoretical basis for better diagnosis and treatment to effectively improve the prognosis of patients with HCC. Dove 2021-08-24 /pmc/articles/PMC8403010/ /pubmed/34466409 http://dx.doi.org/10.2147/JHC.S325593 Text en © 2021 Liao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Liao, Hao
Shi, Juanyi
Wen, Kai
Lin, Jianhong
Liu, Qinghua
Shi, Bingchao
Yan, Yongcong
Xiao, Zhiyu
Molecular Targets of Ferroptosis in Hepatocellular Carcinoma
title Molecular Targets of Ferroptosis in Hepatocellular Carcinoma
title_full Molecular Targets of Ferroptosis in Hepatocellular Carcinoma
title_fullStr Molecular Targets of Ferroptosis in Hepatocellular Carcinoma
title_full_unstemmed Molecular Targets of Ferroptosis in Hepatocellular Carcinoma
title_short Molecular Targets of Ferroptosis in Hepatocellular Carcinoma
title_sort molecular targets of ferroptosis in hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403010/
https://www.ncbi.nlm.nih.gov/pubmed/34466409
http://dx.doi.org/10.2147/JHC.S325593
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