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High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage
OBJECTIVE: Increased level of serum uric acid (UA) is often considered a risk factor for ischemic stroke. However, there are limited data on the association between UA and intracerebral hemorrhage (ICH). This study aimed to examine the connection between UA and early neurological deterioration (END)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403016/ https://www.ncbi.nlm.nih.gov/pubmed/34465996 http://dx.doi.org/10.2147/NDT.S321778 |
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author | Gong, Xiuqun Lu, Zeyu Feng, Xiwu Yuan, Kang Zhang, Mei Cheng, Xiaosi Xue, Min Yu, Liang Lu, Jun Yu, Chuanqing |
author_facet | Gong, Xiuqun Lu, Zeyu Feng, Xiwu Yuan, Kang Zhang, Mei Cheng, Xiaosi Xue, Min Yu, Liang Lu, Jun Yu, Chuanqing |
author_sort | Gong, Xiuqun |
collection | PubMed |
description | OBJECTIVE: Increased level of serum uric acid (UA) is often considered a risk factor for ischemic stroke. However, there are limited data on the association between UA and intracerebral hemorrhage (ICH). This study aimed to examine the connection between UA and early neurological deterioration (END) in patients with ICH. METHODS: This is a prospective observational study. Patients with ICH were enrolled from January 2017 to December 2020. END was diagnosed as the Canadian Stroke Scale (CSS) score decreased ≥1 points between admission and 48 hours. UA was measured at admission. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and END. RESULTS: Of the 498 enrolled patients, 132 (26.5%) were developed with END. Patients with END had a significantly higher level of serum UA (332 vs 270 µmol/L, P < 0.001). Univariate logistic regression analysis indicated that patients with the highest quartile of UA level had an OR of 3.256 (95% CI: 1.849–5.734, P < 0.001) for END compared with those with the lowest quartile of UA level. After adjusting for major confounders, the highest UA quartile remained as an independent predictor for END (OR = 2.282, 95% CI: 1.112–4.685, P = 0.013). CONCLUSION: Higher serum UA level was independently associated with END in patients with ICH; therefore, intervention to lower UA level may be worth considering. |
format | Online Article Text |
id | pubmed-8403016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-84030162021-08-30 High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage Gong, Xiuqun Lu, Zeyu Feng, Xiwu Yuan, Kang Zhang, Mei Cheng, Xiaosi Xue, Min Yu, Liang Lu, Jun Yu, Chuanqing Neuropsychiatr Dis Treat Original Research OBJECTIVE: Increased level of serum uric acid (UA) is often considered a risk factor for ischemic stroke. However, there are limited data on the association between UA and intracerebral hemorrhage (ICH). This study aimed to examine the connection between UA and early neurological deterioration (END) in patients with ICH. METHODS: This is a prospective observational study. Patients with ICH were enrolled from January 2017 to December 2020. END was diagnosed as the Canadian Stroke Scale (CSS) score decreased ≥1 points between admission and 48 hours. UA was measured at admission. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and END. RESULTS: Of the 498 enrolled patients, 132 (26.5%) were developed with END. Patients with END had a significantly higher level of serum UA (332 vs 270 µmol/L, P < 0.001). Univariate logistic regression analysis indicated that patients with the highest quartile of UA level had an OR of 3.256 (95% CI: 1.849–5.734, P < 0.001) for END compared with those with the lowest quartile of UA level. After adjusting for major confounders, the highest UA quartile remained as an independent predictor for END (OR = 2.282, 95% CI: 1.112–4.685, P = 0.013). CONCLUSION: Higher serum UA level was independently associated with END in patients with ICH; therefore, intervention to lower UA level may be worth considering. Dove 2021-08-24 /pmc/articles/PMC8403016/ /pubmed/34465996 http://dx.doi.org/10.2147/NDT.S321778 Text en © 2021 Gong et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Gong, Xiuqun Lu, Zeyu Feng, Xiwu Yuan, Kang Zhang, Mei Cheng, Xiaosi Xue, Min Yu, Liang Lu, Jun Yu, Chuanqing High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
title | High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
title_full | High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
title_fullStr | High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
title_full_unstemmed | High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
title_short | High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
title_sort | high uric acid level predicts early neurological deterioration in intracerebral hemorrhage |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403016/ https://www.ncbi.nlm.nih.gov/pubmed/34465996 http://dx.doi.org/10.2147/NDT.S321778 |
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