Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

BACKGROUND: Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na(+)/H(+) exchanger-1 (NHE1) in reactive astrocytes causes astrocytic hyper...

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Detalles Bibliográficos
Autores principales: Liu, Qian, Bhuiyan, Mohammad Iqbal H., Liu, Ruijia, Song, Shanshan, Begum, Gulnaz, Young, Cullen B., Foley, Lesley M., Chen, Fenghua, Hitchens, T. Kevin, Cao, Guodong, Chattopadhyay, Ansuman, He, Li, Sun, Dandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403348/
https://www.ncbi.nlm.nih.gov/pubmed/34454529
http://dx.doi.org/10.1186/s12974-021-02234-8

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