G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

BACKGROUND: Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction mediated by mechanical stress is still unclear. Here, we elucidate that the crit...

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Detalles Bibliográficos
Autores principales: Sun, Yi, Leng, Ping, Guo, Pengcheng, Gao, Huanshen, Liu, Yikai, Li, Chenkai, Li, Zhenghui, Zhang, Haining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403401/
https://www.ncbi.nlm.nih.gov/pubmed/34454425
http://dx.doi.org/10.1186/s10020-021-00360-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403401/
https://www.ncbi.nlm.nih.gov/pubmed/34454425
http://dx.doi.org/10.1186/s10020-021-00360-w

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