2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model

One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondral plugs in 38 retired Sprague-Dawley rats were crea...

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Detalles Bibliográficos
Autores principales: Gomez, Vincent, Cairns, Mark, Weinhold, Paul, Jeffs, Alexander D, Bortner, Benjamin, Paterno, Anthony V, Dahners, Laurence, Draeger, Reid W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Orthopedics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403484/
https://www.ncbi.nlm.nih.gov/pubmed/34476134
http://dx.doi.org/10.7759/cureus.16758
Descripción
Sumario:One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondral plugs in 38 retired Sprague-Dawley rats were created in both hind legs. Each rat had one plug dipped in 2-OCTA before fixation and one control plug. H&E staining was used to quantify bone bridging. The 2-OCTA group had a mean bridging bone circumference of 22.80%, significantly less than 67.75% in the control group (p<0.05). Our data suggests that 2-OCTA blocks bridging bone formation, making it a poor choice for fracture fixation.

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