2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model

One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondral plugs in 38 retired Sprague-Dawley rats were crea...

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Autores principales: Gomez, Vincent, Cairns, Mark, Weinhold, Paul, Jeffs, Alexander D, Bortner, Benjamin, Paterno, Anthony V, Dahners, Laurence, Draeger, Reid W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Orthopedics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403484/
https://www.ncbi.nlm.nih.gov/pubmed/34476134
http://dx.doi.org/10.7759/cureus.16758
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author Gomez, Vincent
Cairns, Mark
Weinhold, Paul
Jeffs, Alexander D
Bortner, Benjamin
Paterno, Anthony V
Dahners, Laurence
Draeger, Reid W
author_facet Gomez, Vincent
Cairns, Mark
Weinhold, Paul
Jeffs, Alexander D
Bortner, Benjamin
Paterno, Anthony V
Dahners, Laurence
Draeger, Reid W
author_sort Gomez, Vincent
collection PubMed
description One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondral plugs in 38 retired Sprague-Dawley rats were created in both hind legs. Each rat had one plug dipped in 2-OCTA before fixation and one control plug. H&E staining was used to quantify bone bridging. The 2-OCTA group had a mean bridging bone circumference of 22.80%, significantly less than 67.75% in the control group (p<0.05). Our data suggests that 2-OCTA blocks bridging bone formation, making it a poor choice for fracture fixation.
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spelling pubmed-84034842021-09-01 2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model Gomez, Vincent Cairns, Mark Weinhold, Paul Jeffs, Alexander D Bortner, Benjamin Paterno, Anthony V Dahners, Laurence Draeger, Reid W Cureus Orthopedics One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondral plugs in 38 retired Sprague-Dawley rats were created in both hind legs. Each rat had one plug dipped in 2-OCTA before fixation and one control plug. H&E staining was used to quantify bone bridging. The 2-OCTA group had a mean bridging bone circumference of 22.80%, significantly less than 67.75% in the control group (p<0.05). Our data suggests that 2-OCTA blocks bridging bone formation, making it a poor choice for fracture fixation. Cureus 2021-07-30 /pmc/articles/PMC8403484/ /pubmed/34476134 http://dx.doi.org/10.7759/cureus.16758 Text en Copyright © 2021, Gomez et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Orthopedics
Gomez, Vincent
Cairns, Mark
Weinhold, Paul
Jeffs, Alexander D
Bortner, Benjamin
Paterno, Anthony V
Dahners, Laurence
Draeger, Reid W
2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model
title 2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model
title_full 2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model
title_fullStr 2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model
title_full_unstemmed 2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model
title_short 2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model
title_sort 2-octyl cyanoacrylate (dermabond®) inhibits bridging bone formation of articular fractures in a rat model
topic Orthopedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403484/
https://www.ncbi.nlm.nih.gov/pubmed/34476134
http://dx.doi.org/10.7759/cureus.16758
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