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Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction

Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimic...

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Autores principales: Maruyama, Kazuaki, Naemura, Kazuaki, Yoshihara, Kenji, Imanaka-Yoshida, Kyoko, Kurihara, Hiroki, Miyagawa-Tomita, Sachiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403767/
https://www.ncbi.nlm.nih.gov/pubmed/34485941
http://dx.doi.org/10.1016/j.xpro.2021.100775
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author Maruyama, Kazuaki
Naemura, Kazuaki
Yoshihara, Kenji
Imanaka-Yoshida, Kyoko
Kurihara, Hiroki
Miyagawa-Tomita, Sachiko
author_facet Maruyama, Kazuaki
Naemura, Kazuaki
Yoshihara, Kenji
Imanaka-Yoshida, Kyoko
Kurihara, Hiroki
Miyagawa-Tomita, Sachiko
author_sort Maruyama, Kazuaki
collection PubMed
description Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations. For complete details on the use and execution of this protocol, please refer to Maruyama et al. (2021)
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spelling pubmed-84037672021-09-02 Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction Maruyama, Kazuaki Naemura, Kazuaki Yoshihara, Kenji Imanaka-Yoshida, Kyoko Kurihara, Hiroki Miyagawa-Tomita, Sachiko STAR Protoc Protocol Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations. For complete details on the use and execution of this protocol, please refer to Maruyama et al. (2021) Elsevier 2021-08-26 /pmc/articles/PMC8403767/ /pubmed/34485941 http://dx.doi.org/10.1016/j.xpro.2021.100775 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Maruyama, Kazuaki
Naemura, Kazuaki
Yoshihara, Kenji
Imanaka-Yoshida, Kyoko
Kurihara, Hiroki
Miyagawa-Tomita, Sachiko
Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
title Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
title_full Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
title_fullStr Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
title_full_unstemmed Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
title_short Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
title_sort surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403767/
https://www.ncbi.nlm.nih.gov/pubmed/34485941
http://dx.doi.org/10.1016/j.xpro.2021.100775
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