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Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403767/ https://www.ncbi.nlm.nih.gov/pubmed/34485941 http://dx.doi.org/10.1016/j.xpro.2021.100775 |
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author | Maruyama, Kazuaki Naemura, Kazuaki Yoshihara, Kenji Imanaka-Yoshida, Kyoko Kurihara, Hiroki Miyagawa-Tomita, Sachiko |
author_facet | Maruyama, Kazuaki Naemura, Kazuaki Yoshihara, Kenji Imanaka-Yoshida, Kyoko Kurihara, Hiroki Miyagawa-Tomita, Sachiko |
author_sort | Maruyama, Kazuaki |
collection | PubMed |
description | Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations. For complete details on the use and execution of this protocol, please refer to Maruyama et al. (2021) |
format | Online Article Text |
id | pubmed-8403767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84037672021-09-02 Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction Maruyama, Kazuaki Naemura, Kazuaki Yoshihara, Kenji Imanaka-Yoshida, Kyoko Kurihara, Hiroki Miyagawa-Tomita, Sachiko STAR Protoc Protocol Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations. For complete details on the use and execution of this protocol, please refer to Maruyama et al. (2021) Elsevier 2021-08-26 /pmc/articles/PMC8403767/ /pubmed/34485941 http://dx.doi.org/10.1016/j.xpro.2021.100775 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Protocol Maruyama, Kazuaki Naemura, Kazuaki Yoshihara, Kenji Imanaka-Yoshida, Kyoko Kurihara, Hiroki Miyagawa-Tomita, Sachiko Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction |
title | Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction |
title_full | Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction |
title_fullStr | Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction |
title_full_unstemmed | Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction |
title_short | Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction |
title_sort | surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403767/ https://www.ncbi.nlm.nih.gov/pubmed/34485941 http://dx.doi.org/10.1016/j.xpro.2021.100775 |
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