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Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation

The Wnt/β-catenin pathway is a highly conserved, frequently mutated developmental and cancer pathway. Its output is defined mainly by β-catenin’s phosphorylation- and ubiquitylation-dependent proteasomal degradation, initiated by the multi-protein β-catenin destruction complex. The precise mechanism...

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Detalles Bibliográficos
Autores principales:	Ranes, Michael, Zaleska, Mariola, Sakalas, Saira, Knight, Ruth, Guettler, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403986/ https://www.ncbi.nlm.nih.gov/pubmed/34352208 http://dx.doi.org/10.1016/j.molcel.2021.07.013

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