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Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study

BACKGROUND: Adults with cardiopulmonary conditions may be at increased risk of influenza and respiratory syncytial virus (RSV) infection, but it is not well‐established and few data are available from middle‐income countries. METHODS: Using data from a prospective cohort study of influenza vaccine e...

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Autores principales: Praphasiri, Prabda, Shrestha, Manash, Patumanond, Jayanton, Nakphook, Sutthichai, Chawalchitiporn, Sutthinan, Ditsungnoen, Darunee, Dawood, Fatimah S., Mott, Joshua A., Prasert, Kriengkrai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404046/
https://www.ncbi.nlm.nih.gov/pubmed/33764688
http://dx.doi.org/10.1111/irv.12855
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author Praphasiri, Prabda
Shrestha, Manash
Patumanond, Jayanton
Nakphook, Sutthichai
Chawalchitiporn, Sutthinan
Ditsungnoen, Darunee
Dawood, Fatimah S.
Mott, Joshua A.
Prasert, Kriengkrai
author_facet Praphasiri, Prabda
Shrestha, Manash
Patumanond, Jayanton
Nakphook, Sutthichai
Chawalchitiporn, Sutthinan
Ditsungnoen, Darunee
Dawood, Fatimah S.
Mott, Joshua A.
Prasert, Kriengkrai
author_sort Praphasiri, Prabda
collection PubMed
description BACKGROUND: Adults with cardiopulmonary conditions may be at increased risk of influenza and respiratory syncytial virus (RSV) infection, but it is not well‐established and few data are available from middle‐income countries. METHODS: Using data from a prospective cohort study of influenza vaccine effectiveness, we estimated and compared the incidences of influenza and RSV between community‐dwelling Thai adults aged ≥ 65 years with and without cardiopulmonary conditions. During May 2015‐May 2017, older adults in a rural province in Thailand were followed‐up with weekly surveillance for acute respiratory illness (ARI), defined broadly as new onset or worsening of cough with or without fever, and hospitalized ARI. When ill, nasal self‐swabs and/or nasopharyngeal swabs were collected for reverse‐transcription polymerase chain reaction testing. We used Poisson regression to calculate incidence rate ratios (IRR), adjusting for age, sex, current smoking, number of hospital visits, weekly influenza activity, and influenza vaccination. RESULTS: Overall, 3220 adults with a median age of 71 years (IQR 68‐76) were enrolled; 1324 (41.1%) were male; and 313 (9.7%) had ≥1 underlying cardiopulmonary condition, most commonly chronic obstructive pulmonary disease (131; 41.2%) or asthma (73; 23.3%). Participants with cardiopulmonary conditions had higher incidences of ARI, influenza, and RSV than those without (Adjusted IRR: 1.84, 95% CI 1.64‐2.07; 1.86, 95% CI 1.07‐3.26; 2.04, 95% CI 1.11‐3.76, respectively). CONCLUSION: Older adults in rural Thailand with cardiopulmonary conditions have increased rates of ARI, influenza, and RSV infections. Our findings support efforts to ensure this population has access to influenza vaccines and other respiratory illness prevention measures.
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spelling pubmed-84040462021-09-04 Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study Praphasiri, Prabda Shrestha, Manash Patumanond, Jayanton Nakphook, Sutthichai Chawalchitiporn, Sutthinan Ditsungnoen, Darunee Dawood, Fatimah S. Mott, Joshua A. Prasert, Kriengkrai Influenza Other Respir Viruses Original Articles BACKGROUND: Adults with cardiopulmonary conditions may be at increased risk of influenza and respiratory syncytial virus (RSV) infection, but it is not well‐established and few data are available from middle‐income countries. METHODS: Using data from a prospective cohort study of influenza vaccine effectiveness, we estimated and compared the incidences of influenza and RSV between community‐dwelling Thai adults aged ≥ 65 years with and without cardiopulmonary conditions. During May 2015‐May 2017, older adults in a rural province in Thailand were followed‐up with weekly surveillance for acute respiratory illness (ARI), defined broadly as new onset or worsening of cough with or without fever, and hospitalized ARI. When ill, nasal self‐swabs and/or nasopharyngeal swabs were collected for reverse‐transcription polymerase chain reaction testing. We used Poisson regression to calculate incidence rate ratios (IRR), adjusting for age, sex, current smoking, number of hospital visits, weekly influenza activity, and influenza vaccination. RESULTS: Overall, 3220 adults with a median age of 71 years (IQR 68‐76) were enrolled; 1324 (41.1%) were male; and 313 (9.7%) had ≥1 underlying cardiopulmonary condition, most commonly chronic obstructive pulmonary disease (131; 41.2%) or asthma (73; 23.3%). Participants with cardiopulmonary conditions had higher incidences of ARI, influenza, and RSV than those without (Adjusted IRR: 1.84, 95% CI 1.64‐2.07; 1.86, 95% CI 1.07‐3.26; 2.04, 95% CI 1.11‐3.76, respectively). CONCLUSION: Older adults in rural Thailand with cardiopulmonary conditions have increased rates of ARI, influenza, and RSV infections. Our findings support efforts to ensure this population has access to influenza vaccines and other respiratory illness prevention measures. John Wiley and Sons Inc. 2021-03-25 2021-09 /pmc/articles/PMC8404046/ /pubmed/33764688 http://dx.doi.org/10.1111/irv.12855 Text en © 2021 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Praphasiri, Prabda
Shrestha, Manash
Patumanond, Jayanton
Nakphook, Sutthichai
Chawalchitiporn, Sutthinan
Ditsungnoen, Darunee
Dawood, Fatimah S.
Mott, Joshua A.
Prasert, Kriengkrai
Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study
title Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study
title_full Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study
title_fullStr Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study
title_full_unstemmed Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study
title_short Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in Thailand: Findings from a two‐year prospective cohort study
title_sort underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community‐dwelling adults aged ≥ 65 years in thailand: findings from a two‐year prospective cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404046/
https://www.ncbi.nlm.nih.gov/pubmed/33764688
http://dx.doi.org/10.1111/irv.12855
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