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Development of rat metabolic syndrome models: A review

Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the mo...

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Autores principales: Gunawan, Shirly, Aulia, Ahmad, Soetikno, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404106/
https://www.ncbi.nlm.nih.gov/pubmed/34475697
http://dx.doi.org/10.14202/vetworld.2021.1774-1783
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author Gunawan, Shirly
Aulia, Ahmad
Soetikno, Vivian
author_facet Gunawan, Shirly
Aulia, Ahmad
Soetikno, Vivian
author_sort Gunawan, Shirly
collection PubMed
description Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study.
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spelling pubmed-84041062021-09-01 Development of rat metabolic syndrome models: A review Gunawan, Shirly Aulia, Ahmad Soetikno, Vivian Vet World Review Article Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. Veterinary World 2021-07 2021-07-07 /pmc/articles/PMC8404106/ /pubmed/34475697 http://dx.doi.org/10.14202/vetworld.2021.1774-1783 Text en Copyright: © Gunawan, et al. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review Article
Gunawan, Shirly
Aulia, Ahmad
Soetikno, Vivian
Development of rat metabolic syndrome models: A review
title Development of rat metabolic syndrome models: A review
title_full Development of rat metabolic syndrome models: A review
title_fullStr Development of rat metabolic syndrome models: A review
title_full_unstemmed Development of rat metabolic syndrome models: A review
title_short Development of rat metabolic syndrome models: A review
title_sort development of rat metabolic syndrome models: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404106/
https://www.ncbi.nlm.nih.gov/pubmed/34475697
http://dx.doi.org/10.14202/vetworld.2021.1774-1783
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