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Development of rat metabolic syndrome models: A review
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the mo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Veterinary World
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404106/ https://www.ncbi.nlm.nih.gov/pubmed/34475697 http://dx.doi.org/10.14202/vetworld.2021.1774-1783 |
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author | Gunawan, Shirly Aulia, Ahmad Soetikno, Vivian |
author_facet | Gunawan, Shirly Aulia, Ahmad Soetikno, Vivian |
author_sort | Gunawan, Shirly |
collection | PubMed |
description | Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. |
format | Online Article Text |
id | pubmed-8404106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Veterinary World |
record_format | MEDLINE/PubMed |
spelling | pubmed-84041062021-09-01 Development of rat metabolic syndrome models: A review Gunawan, Shirly Aulia, Ahmad Soetikno, Vivian Vet World Review Article Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. Veterinary World 2021-07 2021-07-07 /pmc/articles/PMC8404106/ /pubmed/34475697 http://dx.doi.org/10.14202/vetworld.2021.1774-1783 Text en Copyright: © Gunawan, et al. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Article Gunawan, Shirly Aulia, Ahmad Soetikno, Vivian Development of rat metabolic syndrome models: A review |
title | Development of rat metabolic syndrome models: A review |
title_full | Development of rat metabolic syndrome models: A review |
title_fullStr | Development of rat metabolic syndrome models: A review |
title_full_unstemmed | Development of rat metabolic syndrome models: A review |
title_short | Development of rat metabolic syndrome models: A review |
title_sort | development of rat metabolic syndrome models: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404106/ https://www.ncbi.nlm.nih.gov/pubmed/34475697 http://dx.doi.org/10.14202/vetworld.2021.1774-1783 |
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