Facile and innovative catalytic protocol for intramolecular Friedel–Crafts cyclization of Morita–Baylis–Hillman adducts: Synergistic combination of chiral (salen)chromium(III)/BF(3)·OEt(2) catalysis

The chiral (salen)Cr(III)/BF(3)·OEt(2) catalytic combination was found to be an effective catalyst for intramolecular Friedel–Crafts cyclization of electron-deficient Morita–Baylis–Hillman adducts. In presence of mild reaction conditions the chiral (salen)Cr(III)/BF(3)·OEt(2) complex affords 2-subst...

Descripción completa

Detalles Bibliográficos
Autores principales: Soundararajan, Karthikeyan, Jeyarajan, Helen Ratna Monica, Kamarajapurathu, Raju Subimol, Ayyanoth, Karthik Krishna Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404216/
https://www.ncbi.nlm.nih.gov/pubmed/34497671
http://dx.doi.org/10.3762/bjoc.17.140
Descripción
Sumario:The chiral (salen)Cr(III)/BF(3)·OEt(2) catalytic combination was found to be an effective catalyst for intramolecular Friedel–Crafts cyclization of electron-deficient Morita–Baylis–Hillman adducts. In presence of mild reaction conditions the chiral (salen)Cr(III)/BF(3)·OEt(2) complex affords 2-substituted-1H-indenes from unique substrates of Morita–Baylis–Hillman adducts via an easy operating practical procedure.

Ejemplares similares