Assessment of H3K27me3 immunohistochemistry and combination of NF1 and p16 deletions by fluorescence in situ hybridization in the differential diagnosis of malignant peripheral nerve sheath tumor and its histological mimics

BACKGROUND: A definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1 (NF1), because MPNST lacks specific markers on immunohistochemistry (IHC). METHODS: We performed IHC for histone 3 trimethylated on lysine 27 (H3K27me...

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Detalles Bibliográficos
Autores principales: Sugita, Shintaro, Aoyama, Tomoyuki, Emori, Makoto, Kido, Tomomi, Takenami, Tomoko, Sakuraba, Kodai, Terai, Kotomi, Sugawara, Taro, Tsujiwaki, Mitsuhiro, Hasegawa, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404283/
https://www.ncbi.nlm.nih.gov/pubmed/34461930
http://dx.doi.org/10.1186/s13000-021-01140-0

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