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Modeling PTEN overexpression-induced microcephaly in human brain organoids

The phosphatase and tensin homolog (PTEN) protein, encoded by the PTEN gene on chromosome 10, is a negative regulator of the phosphoinositide 3-kinase (PI3K) signaling pathway. Loss of PTEN has been linked to an array of human diseases, including neurodevelopmental disorders such as macrocephaly and...

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Detalles Bibliográficos
Autores principales:	Dhaliwal, Navroop, Choi, Wendy W.Y., Muffat, Julien, Li, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Micro Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404342/ https://www.ncbi.nlm.nih.gov/pubmed/34461955 http://dx.doi.org/10.1186/s13041-021-00841-3

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