Cargando…

Phase 3 randomised trial of eltrombopag versus standard first-line pharmacological management for newly diagnosed immune thrombocytopaenia (ITP) in children: study protocol

INTRODUCTION: Immune thrombocytopaenia (ITP) is an acquired disorder of low platelets and risk of bleeding. Although many children can be observed until spontaneous remission, others require treatment due to bleeding or impact on health-related quality of life. Standard first-line therapies for thos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shimano, Kristin A, Grace, Rachael F, Despotovic, Jenny M, Neufeld, Ellis J, Klaassen, Robert J, Bennett, Carolyn M, Ma, Clement, London, Wendy B, Neunert, Cindy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Haematology (Incl Blood Transfusion)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404450/ https://www.ncbi.nlm.nih.gov/pubmed/34452956 http://dx.doi.org/10.1136/bmjopen-2020-044885

Ejemplares similares

Long-term psychosocial impact of venous thromboembolism: a qualitative study in the community
por: Hunter, Rachael, et al.
Publicado: (2019)

Trial protocol: a multicentre randomised trial of first-line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The FLIGHT trial
por: Pell, Julie, et al.
Publicado: (2018)

Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study
por: Gates, Priscilla, et al.
Publicado: (2020)

Low-dose intravenous immunoglobulin for children with newly diagnosed immune thrombocytopenia: protocol of a systematic review and meta-analysis
por: Ren, Xiangge, et al.
Publicado: (2023)

Defining a set of standardised outcome measures for newly diagnosed patients with multiple myeloma using the Delphi consensus method: the IMPORTA project
por: Blade, Joan, et al.
Publicado: (2018)

Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III trial
por: Coulson, Amy Beth, et al.
Publicado: (2022)

Haematological profile of chronic kidney disease in a mixed-ancestry South African population: a cross-sectional study
por: George, Cindy, et al.
Publicado: (2018)

MUKnine OPTIMUM protocol: a screening study to identify high-risk patients with multiple myeloma suitable for novel treatment approaches combined with a phase II study evaluating optimised combination of biological therapy in newly diagnosed high-risk multiple myeloma and plasma cell leukaemia
por: Brown, Sarah, et al.
Publicado: (2021)

Cryopreserved platelets compared with liquid-stored platelets for the treatment of surgical bleeding: protocol for two multicentre randomised controlled blinded non-inferiority trials (the CLIP-II and CLIPNZ-II trials)
por: Reade, Michael C., et al.
Publicado: (2022)

Are survival and mortality rates associated with recruitment to clinical trials in teenage and young adult patients with acute lymphoblastic leukaemia? A retrospective observational analysis in England
por: Hough, Rachael, et al.
Publicado: (2017)

Behaviour modification interventions to optimise red blood cell transfusion practices: a systematic review and meta-analysis
por: Soril, Lesley J J, et al.
Publicado: (2018)

Risk of infection associated with intravenous iron preparations: protocol for updating a systematic review
por: Shah, Akshay, et al.
Publicado: (2019)

The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design
por: Grace, Rachael F, et al.
Publicado: (2023)

Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana
por: Anie, Kofi A, et al.
Publicado: (2017)

Sickle Cell Disease Genomics of Africa (SickleGenAfrica) Network: ethical framework and initial qualitative findings from community engagement in Ghana, Nigeria and Tanzania
por: Anie, Kofi A, et al.
Publicado: (2021)

Determinants of adherence and consequences of the transition from adolescence to adulthood among young people with severe haemophilia (TRANSHEMO): study protocol for a multicentric French national observational cross-sectional study
por: Resseguier, Noémie, et al.
Publicado: (2018)

Risk Factors for Alloimmunisation after red blood Cell Transfusions (R-FACT): a case cohort study
por: Zalpuri, Saurabh, et al.
Publicado: (2012)

Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease
por: Anie, Kofi A, et al.
Publicado: (2012)

Assessment of whole body MRI and sestamibi technetium-99m bone marrow scan in prediction of multiple myeloma disease progression and outcome: a prospective comparative study
por: Khalafallah, Alhossain A, et al.
Publicado: (2013)

Stem cell transplantation of matched sibling donors compared with immunosuppressive therapy for acquired severe aplastic anaemia: a Cochrane systematic review
por: Peinemann, Frank, et al.
Publicado: (2014)

Current practice of venous thromboembolism prevention in acute trusts: a qualitative study
por: McFarland, L, et al.
Publicado: (2014)

An audit of anticoagulant management to assess anticoagulant control using decision support software
por: Harper, Paul, et al.
Publicado: (2014)

Randomised controlled trial of weekly chloroquine to re-establish normal erythron iron flux and haemoglobin recovery in postmalarial anaemia
por: Cox, Sharon E, et al.
Publicado: (2013)

Intracranial haemorrhage in thrombocytopenic haematology patients—a nested case–control study: the InCiTe study protocol
por: Estcourt, Lise J, et al.
Publicado: (2014)

HFE gene mutation and oxidative damage biomarkers in patients with myelodysplastic syndromes and its relation to transfusional iron overload: an observational cross-sectional study
por: De Souza, Geane Felix, et al.
Publicado: (2015)

A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial
por: Ypma, Paula F, et al.
Publicado: (2016)

Validation of the multivariable In-hospital Mortality for PulmonAry embolism using Claims daTa (IMPACT) prediction rule within an all-payer inpatient administrative claims database
por: Coleman, Craig I, et al.
Publicado: (2015)

Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction: a retrospective analysis of comparing haematological parameters and C reactive protein
por: Lee, Jong-Han, et al.
Publicado: (2014)

Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol
por: Schünemann, Holger J, et al.
Publicado: (2016)

Protocol for updating a systematic review of randomised controlled trials on the prophylactic use of intravenous immunoglobulin for patients undergoing haematopoietic stem cell transplantation
por: Cowan, Juthaporn, et al.
Publicado: (2015)

Clinical effects of blood donor characteristics in transfusion recipients: protocol of a framework to study the blood donor–recipient continuum
por: Chassé, Michaël, et al.
Publicado: (2015)

Is self-monitoring an effective option for people receiving long-term vitamin K antagonist therapy? A systematic review and economic evaluation
por: Sharma, Pawana, et al.
Publicado: (2015)

Mutation screening for thalassaemia in the Jino ethnic minority population of Yunnan Province, Southwest China
por: Wang, Shiyun, et al.
Publicado: (2015)

Health-related quality of life after pulmonary embolism: a cross-sectional study
por: Tavoly, Mazdak, et al.
Publicado: (2016)

Gender disparities in red blood cell transfusion in elective surgery: a post hoc multicentre cohort study
por: Gombotz, Hans, et al.
Publicado: (2016)

Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol
por: English, Shane W, et al.
Publicado: (2016)

Rationale and design of platelet transfusions in haematopoietic stem cell transplantation: the PATH pilot study
por: Tay, Jason, et al.
Publicado: (2016)

Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol
por: Tang, Xiao-Yi, et al.
Publicado: (2016)

Antithrombotic stewardship: a multidisciplinary team approach towards improving antithrombotic therapy outcomes during and after hospitalisation: a study protocol
por: Dreijer, Albert R, et al.
Publicado: (2016)

Is it feasible to conduct a randomised controlled trial of pretransplant exercise (prehabilitation) for patients with multiple myeloma awaiting autologous haematopoietic stem cell transplantation? Protocol for the PREeMPT study
por: Keen, Carol, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q04qp99lea99qfculfpn104u21