Cargando…

Translational regulation in the brain by TDP-43 phase separation

The in vivo physiological function of liquid–liquid phase separation (LLPS) that governs non–membrane-bound structures remains elusive. Among LLPS-prone proteins, TAR DNA-binding protein of 43 kD (TDP-43) is under intense investigation because of its close association with neurological disorders. He...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Ju, Wang, Luwen, Ren, Xiaojia, Dunn, Justin R., Peters, Ariele, Miyagi, Masaru, Fujioka, Hisashi, Zhao, Fangli, Askwith, Candice, Liang, Jingjing, Wang, Xinglong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404466/ https://www.ncbi.nlm.nih.gov/pubmed/34427634 http://dx.doi.org/10.1083/jcb.202101019

Ejemplares similares

The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity
por: Wang, Wenzhang, et al.
Publicado: (2016)

Association Between TDP-43 and Mitochondria in Inclusion Body Myositis
por: Huntley, Mikayla L., et al.
Publicado: (2019)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

Phase separation-deficient TDP43 remains functional in splicing
por: Schmidt, Hermann Broder, et al.
Publicado: (2019)

TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation
por: Koehler, Lydia C., et al.
Publicado: (2022)

Structural Insights Into TDP-43 and Effects of Post-translational Modifications
por: François-Moutal, Liberty, et al.
Publicado: (2019)

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
por: Yan, Tingxiang, et al.
Publicado: (2020)

Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
por: Yan, Tingxiang, et al.
Publicado: (2022)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

TDP-43 Pathology in Alzheimer’s Disease
por: Meneses, Axel, et al.
Publicado: (2021)

Corrigendum: Structural Insights Into TDP-43 and Effects of Post-translational Modifications
por: François-Moutal, Liberty, et al.
Publicado: (2020)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
por: Ren, Yuting, et al.
Publicado: (2021)

TDP-43 crosses the divide
por: Leslie, Mitch
Publicado: (2015)

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
por: Xie, Manling, et al.
Publicado: (2021)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Huang, Wendi, et al.
Publicado: (2020)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
por: Atkinson, Rachel, et al.
Publicado: (2021)

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
por: Rengifo-Gonzalez, Juan Carlos, et al.
Publicado: (2021)

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
por: Keating, Sean S., et al.
Publicado: (2023)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease
por: Neelagandan, Nagammal, et al.
Publicado: (2019)

TDP-43 α-helical structure tunes liquid–liquid phase separation and function
por: Conicella, Alexander E., et al.
Publicado: (2020)

Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases
por: Carey, Jenny L., et al.
Publicado: (2022)

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
por: Neumann, Manuela, et al.
Publicado: (2020)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
por: Necarsulmer, Julie C, et al.
Publicado: (2023)

The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43
por: Xu, Ya-Fei, et al.
Publicado: (2013)

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
por: Oiwa, Kotaro, et al.
Publicado: (2023)

High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy
por: An, Shanshan, et al.
Publicado: (2020)

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice
por: Ding, Xuebing, et al.
Publicado: (2021)

TDP-43 suppresses tau expression via promoting its mRNA instability
por: Gu, Jianlan, et al.
Publicado: (2017)

Molecular Neuropathology of TDP-43 Proteinopathies
por: Neumann, Manuela
Publicado: (2009)

Mechanisms and models of TDP-43 proteinopathies
por: Petrucelli, Leonard
Publicado: (2012)

Drosophila Answers to TDP-43 Proteinopathies
por: Romano, Maurizio, et al.
Publicado: (2012)

Metals in ALS TDP-43 Pathology
por: Koski, Lassi, et al.
Publicado: (2021)

Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation
por: Pakravan, Donya, et al.
Publicado: (2021)

Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling
por: D’Alton, Simon, et al.
Publicado: (2014)

TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins
por: Prpar Mihevc, S., et al.
Publicado: (2016)

An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration
por: Flores, Brittany N., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cemh4bljruev8k4n8r8i88is6f