Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine

Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions. As close relatives of humans, nonhuman primates (NHPs) play an increasingly indispensable role in advancing translational m...

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Detalles Bibliográficos
Autores principales: Huang, Mei, Yang, Jiao, Li, Peng, Chen, Yongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404551/
https://www.ncbi.nlm.nih.gov/pubmed/34549187
http://dx.doi.org/10.34133/2021/9898769
Descripción
Sumario:Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions. As close relatives of humans, nonhuman primates (NHPs) play an increasingly indispensable role in advancing translational medicine research. In this review, we summarized the progress of NHP models generated by embryo engineering, analyzed their unique advantages in mimicking clinical patients, and discussed the remaining gap between basic research of NHP models to translational medicine.

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