Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine

Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions. As close relatives of humans, nonhuman primates (NHPs) play an increasingly indispensable role in advancing translational m...

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Detalles Bibliográficos
Autores principales: Huang, Mei, Yang, Jiao, Li, Peng, Chen, Yongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404551/
https://www.ncbi.nlm.nih.gov/pubmed/34549187
http://dx.doi.org/10.34133/2021/9898769
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author Huang, Mei
Yang, Jiao
Li, Peng
Chen, Yongchang
author_facet Huang, Mei
Yang, Jiao
Li, Peng
Chen, Yongchang
author_sort Huang, Mei
collection PubMed
description Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions. As close relatives of humans, nonhuman primates (NHPs) play an increasingly indispensable role in advancing translational medicine research. In this review, we summarized the progress of NHP models generated by embryo engineering, analyzed their unique advantages in mimicking clinical patients, and discussed the remaining gap between basic research of NHP models to translational medicine.
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spelling pubmed-84045512021-09-20 Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine Huang, Mei Yang, Jiao Li, Peng Chen, Yongchang Research (Wash D C) Review Article Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions. As close relatives of humans, nonhuman primates (NHPs) play an increasingly indispensable role in advancing translational medicine research. In this review, we summarized the progress of NHP models generated by embryo engineering, analyzed their unique advantages in mimicking clinical patients, and discussed the remaining gap between basic research of NHP models to translational medicine. AAAS 2021-08-21 /pmc/articles/PMC8404551/ /pubmed/34549187 http://dx.doi.org/10.34133/2021/9898769 Text en Copyright © 2021 Mei Huang et al. https://creativecommons.org/licenses/by/4.0/Exclusive Licensee Science and Technology Review Publishing House. Distributed under a Creative Commons Attribution License (CC BY 4.0).
spellingShingle Review Article
Huang, Mei
Yang, Jiao
Li, Peng
Chen, Yongchang
Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine
title Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine
title_full Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine
title_fullStr Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine
title_full_unstemmed Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine
title_short Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine
title_sort embryo-engineered nonhuman primate models: progress and gap to translational medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404551/
https://www.ncbi.nlm.nih.gov/pubmed/34549187
http://dx.doi.org/10.34133/2021/9898769
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AT lipeng embryoengineerednonhumanprimatemodelsprogressandgaptotranslationalmedicine
AT chenyongchang embryoengineerednonhumanprimatemodelsprogressandgaptotranslationalmedicine

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