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Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison

Objective In China, polyene phosphatidylcholine (PPC) is widely used to treat alanine aminotransferase (ALT) elevation associated with various liver diseases. Here, we assessed the efficacy and safety of PPC in treating drug-induced liver injury (DILI). Methods Data from a multicenter retrospective...

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Autores principales: Lei, Xiaohong, Zhang, Jianzhong, Xu, Qingling, Li, Jing, Qian, Yunsong, Zhang, Jing, Liu, Liangming, Zhong, Wei, Wang, Yongfeng, Han, Xian, Tang, Jieting, Zeng, Minde, Mao, Yimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404657/
https://www.ncbi.nlm.nih.gov/pubmed/34433332
http://dx.doi.org/10.1177/03000605211039810
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author Lei, Xiaohong
Zhang, Jianzhong
Xu, Qingling
Li, Jing
Qian, Yunsong
Zhang, Jing
Liu, Liangming
Zhong, Wei
Wang, Yongfeng
Han, Xian
Tang, Jieting
Zeng, Minde
Mao, Yimin
author_facet Lei, Xiaohong
Zhang, Jianzhong
Xu, Qingling
Li, Jing
Qian, Yunsong
Zhang, Jing
Liu, Liangming
Zhong, Wei
Wang, Yongfeng
Han, Xian
Tang, Jieting
Zeng, Minde
Mao, Yimin
author_sort Lei, Xiaohong
collection PubMed
description Objective In China, polyene phosphatidylcholine (PPC) is widely used to treat alanine aminotransferase (ALT) elevation associated with various liver diseases. Here, we assessed the efficacy and safety of PPC in treating drug-induced liver injury (DILI). Methods Data from a multicenter retrospective cohort study (DILI-R) were analyzed to compare PPC and magnesium isoglycyrrhizinate (MgIG) for treatment of DILI. We used the Roussel Uclaf causality assessment method (RUCAM) to evaluate patients with DILI. Patients with RUCAM scores ≥6 were included in the study, while those with RUCAM scores <6 were further evaluated by a panel of hepatologists. The primary outcome was the proportion of patients with ALT normalization at discharge. Propensity score matching was used to identify 183 matched pairs of patients (366 patients in total) from 25,927 patients with DILI. Results Among the DILI patients, 64 of 183 (34.97%) achieved normal ALT levels after treatment in both the PPC and the MgIG groups. Conclusion There were no significant differences in safety biomarkers including serum creatinine, blood urea nitrogen, white blood cells, platelets, hemoglobin, and albumin between patients treated with PPC or MgIG. The safety and efficacy of these two agents for treatment of DILI were comparable.
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spelling pubmed-84046572021-08-31 Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison Lei, Xiaohong Zhang, Jianzhong Xu, Qingling Li, Jing Qian, Yunsong Zhang, Jing Liu, Liangming Zhong, Wei Wang, Yongfeng Han, Xian Tang, Jieting Zeng, Minde Mao, Yimin J Int Med Res Retrospective Clinical Research Report Objective In China, polyene phosphatidylcholine (PPC) is widely used to treat alanine aminotransferase (ALT) elevation associated with various liver diseases. Here, we assessed the efficacy and safety of PPC in treating drug-induced liver injury (DILI). Methods Data from a multicenter retrospective cohort study (DILI-R) were analyzed to compare PPC and magnesium isoglycyrrhizinate (MgIG) for treatment of DILI. We used the Roussel Uclaf causality assessment method (RUCAM) to evaluate patients with DILI. Patients with RUCAM scores ≥6 were included in the study, while those with RUCAM scores <6 were further evaluated by a panel of hepatologists. The primary outcome was the proportion of patients with ALT normalization at discharge. Propensity score matching was used to identify 183 matched pairs of patients (366 patients in total) from 25,927 patients with DILI. Results Among the DILI patients, 64 of 183 (34.97%) achieved normal ALT levels after treatment in both the PPC and the MgIG groups. Conclusion There were no significant differences in safety biomarkers including serum creatinine, blood urea nitrogen, white blood cells, platelets, hemoglobin, and albumin between patients treated with PPC or MgIG. The safety and efficacy of these two agents for treatment of DILI were comparable. SAGE Publications 2021-08-25 /pmc/articles/PMC8404657/ /pubmed/34433332 http://dx.doi.org/10.1177/03000605211039810 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Lei, Xiaohong
Zhang, Jianzhong
Xu, Qingling
Li, Jing
Qian, Yunsong
Zhang, Jing
Liu, Liangming
Zhong, Wei
Wang, Yongfeng
Han, Xian
Tang, Jieting
Zeng, Minde
Mao, Yimin
Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison
title Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison
title_full Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison
title_fullStr Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison
title_full_unstemmed Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison
title_short Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison
title_sort exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the roussel uclaf causality assessment method: a propensity score matching comparison
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404657/
https://www.ncbi.nlm.nih.gov/pubmed/34433332
http://dx.doi.org/10.1177/03000605211039810
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