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A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis
A 53-year-old man presented with asymptomatic, dusky reddish nodules on his trunk, which had persisted for 7 years. Histological findings showed nodular to diffuse dermal infiltration of lymphocytes with irregular nuclei, eosinophils, plasma cells, and mast cells. CD20 revealed patch positivity. Per...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404676/ https://www.ncbi.nlm.nih.gov/pubmed/34471539 http://dx.doi.org/10.1177/2050313X211042527 |
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author | Lee, Hyun Yi Lee, Joong Sun Koo, Dae Won |
author_facet | Lee, Hyun Yi Lee, Joong Sun Koo, Dae Won |
author_sort | Lee, Hyun Yi |
collection | PubMed |
description | A 53-year-old man presented with asymptomatic, dusky reddish nodules on his trunk, which had persisted for 7 years. Histological findings showed nodular to diffuse dermal infiltration of lymphocytes with irregular nuclei, eosinophils, plasma cells, and mast cells. CD20 revealed patch positivity. Periphery of lymphoid follicles showed BCL-2 positivity and BCL-6 positivity focally at the center. CD30 and toluidine blue staining showed positivity, and several mast cells were confirmed. The immunoglobulin heavy chain gene rearrangement result showed B-cell monoclonality. The patient’s condition was diagnosed as cutaneous marginal zone B-cell lymphoma, plasmacytoid type with mastocytosis. Primary cutaneous marginal zone B-cell lymphoma is an indolent lymphoma with a tendency for local recurrence. In the specimen obtained from our patient, multiple mast cells were observed. Primary cutaneous marginal zone B-cell lymphoma with prominent mastocytosis is rare and there are a few reported cases. Therefore, this case is worth reporting for its rarity and for the purpose of reminding mastocytosis in primary cutaneous marginal zone B-cell lymphoma. |
format | Online Article Text |
id | pubmed-8404676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-84046762021-08-31 A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis Lee, Hyun Yi Lee, Joong Sun Koo, Dae Won SAGE Open Med Case Rep JCMS case report A 53-year-old man presented with asymptomatic, dusky reddish nodules on his trunk, which had persisted for 7 years. Histological findings showed nodular to diffuse dermal infiltration of lymphocytes with irregular nuclei, eosinophils, plasma cells, and mast cells. CD20 revealed patch positivity. Periphery of lymphoid follicles showed BCL-2 positivity and BCL-6 positivity focally at the center. CD30 and toluidine blue staining showed positivity, and several mast cells were confirmed. The immunoglobulin heavy chain gene rearrangement result showed B-cell monoclonality. The patient’s condition was diagnosed as cutaneous marginal zone B-cell lymphoma, plasmacytoid type with mastocytosis. Primary cutaneous marginal zone B-cell lymphoma is an indolent lymphoma with a tendency for local recurrence. In the specimen obtained from our patient, multiple mast cells were observed. Primary cutaneous marginal zone B-cell lymphoma with prominent mastocytosis is rare and there are a few reported cases. Therefore, this case is worth reporting for its rarity and for the purpose of reminding mastocytosis in primary cutaneous marginal zone B-cell lymphoma. SAGE Publications 2021-08-28 /pmc/articles/PMC8404676/ /pubmed/34471539 http://dx.doi.org/10.1177/2050313X211042527 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | JCMS case report Lee, Hyun Yi Lee, Joong Sun Koo, Dae Won A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis |
title | A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis |
title_full | A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis |
title_fullStr | A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis |
title_full_unstemmed | A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis |
title_short | A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis |
title_sort | case report of primary cutaneous marginal zone b-cell lymphoma with mastocytosis |
topic | JCMS case report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404676/ https://www.ncbi.nlm.nih.gov/pubmed/34471539 http://dx.doi.org/10.1177/2050313X211042527 |
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