Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

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Although mRNA vaccines prevent COVID-19, variants jeopardize their efficacy as immunity wanes. Here, we assessed the immunogenicity and protective activity of historical (mRNA-1273, designed for Wuhan-1 spike) or modified (mRNA-1273.351, designed for B.1.351 spike) preclinical Moderna mRNA vaccines...

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Detalles Bibliográficos
Autores principales: Ying, Baoling, Whitener, Bradley, VanBlargan, Laura A., Hassan, Ahmed O., Shrihari, Swathi, Liang, Chieh-Yu, Karl, Courtney E., Mackin, Samantha, Chen, Rita E., Kafai, Natasha M., Wilks, Samuel H., Smith, Derek J., Carreño, Juan Manuel, Singh, Gagandeep, Krammer, Florian, Carfi, Andrea, Elbashir, Sayda, Edwards, Darin K., Thackray, Larissa B., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404887/
https://www.ncbi.nlm.nih.gov/pubmed/34462745
http://dx.doi.org/10.1101/2021.08.25.457693
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