Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

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BACKGROUND: Sphingosine-1-phosphate receptor (S1P) modulators and antiCD20 therapies impair humoral responses to SARS-CoV-2 mRNA vaccines. Whether disease modifying therapies (DMTs) for multiple sclerosis (MS) also impact T cell immune response to vaccination is unknown. METHODS: In 101 people with...

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Detalles Bibliográficos
Autores principales: Gadani, Sachin P., Reyes-Mantilla, Maria, Jank, Larissa, Harris, Samantha, Douglas, Morgan, Smith, Matthew D., Calabresi, Peter A., Mowry, Ellen M., Fitzgerald, Kathryn C., Bhargava, Pavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404904/
https://www.ncbi.nlm.nih.gov/pubmed/34462762
http://dx.doi.org/10.1101/2021.08.23.21262472
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