Upper airway gene expression reveals a more robust innate and adaptive immune response to SARS-CoV-2 in children compared with older adults

Unlike other respiratory viruses, SARS-CoV-2 disproportionately causes severe disease in older adults and only rarely in children. To investigate whether differences in the upper airway immune response could contribute to this disparity, we compared nasopharyngeal gene expression in 83 children (<...

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Detalles Bibliográficos
Autores principales: Mick, Eran, Tsitsiklis, Alexandra, Spottiswoode, Natasha, Caldera, Saharai, Serpa, Paula Hayakawa, Detweiler, Angela M., Neff, Norma, Pisco, Angela Oliveira, Li, Lucy M., Retallack, Hanna, Ratnasiri, Kalani, Williamson, Kayla M., Soesanto, Victoria, Simões, Eric A. F., Kistler, Amy, Wagner, Brandie D., DeRisi, Joseph L., Ambroggio, Lilliam, Mourani, Peter M., Langelier, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404906/
https://www.ncbi.nlm.nih.gov/pubmed/34462739
http://dx.doi.org/10.21203/rs.3.rs-784784/v1

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